Dymista® Nasal Spray
(Fluticasone propionate/Azelastine hydrochloride)
2025/07/30
Dymista Nasal Spray contains two active substances - azelastine and fluticasone.
Azelastine belongs to a group of medicines called antihistamines. Antihistamines work by preventing the effects of substances such as histamine that the body produces as part of an allergic reaction, thus reducing symptoms of allergic rhinitis.
Fluticasone belongs to a group of medicines called corticosteroids which reduces inflammation.
The Dymista Nasal Spray helps to reduce symptoms of allergic rhinitis such as sneezing, itchiness and runny or blocked nose.
Do not stop taking your medication without checking with your healthcare professional.
Preparing the new device
| Steps | Description |
|---|
| 1 | Shake the bottle gently for 5 seconds by tilting it upwards and downwards and then remove the protective cap (see figure 1). 
|
| 2 | The first time the nasal spray is used, you must prime the pump by squirting it into the air.
Prime the pump by putting two fingers on either side of the spray pump and place your thumb on the bottom of the bottle. Press down and release the pump 6 times until a fine mist appears (see figure 2). 
|
| 3 | If the nasal spray has not been used for more than 7 days, you will need to re-prime the pump once by pressing down and releasing the pump. |
Administering the medication
| Steps | Description |
|---|
| 1 | Shake the bottle gently by tilting it upwards and downwards and then remove the protective cap (see figure 1). |
| 2 | Blow your nose to clear the nostrils and tilt your head slightly downwards towards your toes. Do not tilt head backwards. |
| 3 | Hold the bottle upright and carefully insert the spray tip into one nostril. |
| 4 | Position the nozzle such that it is pointing away from the centre of the nose (towards the ears). Pointing it to the centre of the nose can increase the risk of nosebleed. |
| 5 | Close other nostril with your finger, rapidly press down once and sniff gently at the same time (see figure 3). 
|
| 6 | Remove the nozzle and breathe out through your mouth. |
| 7 | Repeat steps 3 to 6 for the other nostril. |
Cleaning the device
- Wipe the nozzle and inside of the cap with a clean and dry tissue after each use.
- Do not push any sharp objects into the nozzle. Repeat steps for preparing the new device if you think that the nozzle is blocked.
If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.
Do not use more than one spray in each nostril twice a day.
Inform your healthcare professional if:
- You are allergic to this medication or any of the other ingredients of this medication.
- You are pregnant, planning to become pregnant, or breastfeeding.
- You have conditions such as:
- A recent operation on your nose.
- An infection in your nose. Infections of the nasal airways should be treated with antibacterial or antifungal medication. If you are given medication for an infection in your nose you can continue to use Dymista Nasal Spray to treat your allergies.
- Tuberculosis or an untreated infection.
- A change in vision or a history of increased ocular pressure, glaucoma and/or cataracts. If this applies to you, you will be closely monitored whilst using Dymista Nasal Spray.
- You suffer from a severe liver disease. Your risk of suffering from systemic side effects is increased.
- Under the age of 6 years old.
Some common side effects include:
- Epistaxis, headache
- A bitter taste in your mouth (this is usually temporary, tilt forward when you are using the nasal spray)
- Unpleasant smell
- Drowsiness or dizziness (avoid driving, operating machinery or other activities which require concentration while on this medication)
- Nosebleed
- Nose discomfort or irritation (this is usually temporary, try to spray away from the centre of the nose)
These side effects may or may not occur, but if they do, they should improve over time. Please approach your healthcare provider if they are bothersome or do not improve.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. Do not keep the nasal spray for more than six months after you have opened it.
Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.
Disclaimer:
- Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.
- If you take more than the recommended dose, please seek medical advice immediately.
- The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
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