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Research Stories

Keep abreast of the latest research stories and trends happening at NUHS, as featured in The Straits Times, Channel NewsAsia, Lianhe Zaobao, Lianhe Wanbao, Berita Harian, as well as other local and overseas media.

Landmark study on new drug to slow progression of Alzheimer's disease
06 Dec 2022

Lecanemab shown to slow cognitive decline in study involving 1,795 participants at early stage of Alzheimer’s disease​.

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Novel combined therapy shows promise for controlling metastatic breast cancer
24 Jun 2022

​Researchers from the National University Cancer Institute, Singapore (NCIS) and Cancer Science Institute of Singapore (CSI Singapore) at National University of Singapore found that combining two drugs, letrozole and lenvatinib, might help those with advanced-stage breast cancer better control the disease with half of those given the combined therapy saw their tumours shrink or experienced good control of the disease for more than six months. 

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NCIS offers scalp cooling therapy to reduce chemo hair loss among patients with cancer
29 Jan 2022
Losing hair from chemotherapy can be very distressing for many patients with cancer and can contribute to a patient’s stress and anxiety. The National University Cancer Institute, Singapore (NCIS) at the NUH now offers scalp cooling therapy to patients undergoing certain types of chemotherapy that may cause hair loss. A study showed over 50 per cent of patients reported hair preservation and those who had hair loss experienced improved rate of hair regrowth.

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Singapore scientists identify new bacteria that may help researchers better understand human infections
14 Dec 2021

​Singapore scientists have identified and named a new species of bacteria, Staphylococcus singaporensis sp.nov, named after Singapore. This newly-described pathogen is part of the Staphylococcus aureus (S. aureus) complex. S. aureus is a common bacterial cause of infections. Infections range from skin and wound infections, surgical infections, to blood stream infections which may be fatal. 

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Atlas of gastric cancer cells maps path to better treatment
16 Nov 2021

Singapore scientists including Dr Raghav Sundar, Consultant, Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS), have created an intricate atlas of gastric cancer cells to offer more insight into how they can spread within the body. 

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New glaucoma implant helps take the pressure off patients
14 Nov 2021

​A team of NUHS clinicians-scientists led by Prof Paul Chew, Department of Ophthalmology at NUS Medicine and Senior Consultant at NUH, has developed a glaucoma implant that helps to reduce patients’ eye pressure for a longer period of time, enabling less reliance on eye drops. 

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NUH neurosurgeons initiated study to assess feasibility of using holographic technology to spatially locate brain tumours
12 Aug 2021

The National University Health System (NUHS) has embarked on a research and development programme within the academic healthcare cluster to explore the use of MR technology in clinical care. As part of the first phase of the research programme, a team of neurosurgeons at NUH has initiated a study to assess the feasibility of using holographic technology to spatially locate brain tumours when operating on patients. 

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Clinician-scientists from NUHS awarded $4.9 million grant to further develop the mitral valve bioprosthesis
01 Jul 2021

​Clinician-scientists from NUHS awarded $4.9 million grant to further develop the mitral valve bioprosthesis, named SingValve, which mimics the exact appearance, form and physical properties of a human mitral valve.

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Boy who is obese & overweight
12 May 2021

​Adults with severe obesity who undergo metabolic-bariatric surgery (MBS) to lose weight, may have substantially lower mortality rates and longer life expectancy compared to those who tried to lose weight through conventional obesity management. The study findings by a team of clinicians and researchers from the National University Hospital (NUH), NUS Saw Swee Hock School of Public Health (SSHSPH) and NUS Yong Loo Lin School of Medicine (NUS Medicine) are published in the prestigious medical journal The Lancet in May.

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Dormitory COVID-19 Swab Exercise
25 Apr 2021

​Two widely-used therapies – oral hydroxychloroquine and povidone-iodine throat spray – have been found to significantly reduce the risk of COVID-19 infection, according to a study by a team of NUHS clinician-scientists.

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Dr Anand Jeyasekharan
13 Apr 2021

​A widely available cancer drug could potentially be used to treat COVID-19, found researchers from the National University Cancer Institute, Singapore - NCIS and the Icahn School of Medicine at Mount Sinai in the United States. The team found in pre-clinical trials that the drug, Topotecan, reduces the severity and death rate of SARS-CoV-2 infection by inhibiting the expression of inflammatory genes in lung models. This could have potential implications for COVID-19 treatment in humans, said NCIS.

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New aerosolized chemotherapy could help end-stage cancer patients live longer
24 Mar 2021

​A novel drug delivery technique that could extend the lifespans of advanced cancer patients has been successfully introduced in Singapore, at the National University Hospital - NUH and National University Cancer Institute, Singapore - NCIS — and for the first time in Asia. Known as pressurised intraperitoneal aerosol chemotherapy (PIPAC), the procedure targets cancers within the peritoneal cavity in the abdomen, including colon, gastric, and ovarian cancer.

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OneNUHS research team’s breakthrough in developing an incredible tool for gastric cancer detection
23 Oct 2020

​After 8 years of discovery research, product development and clinical validation involving 5,248 subjects from Singapore and South Korea, NUHS has developed a non-invasive blood-based test targeting gastric cancer, more accurate than any of the existing conventional blood-based biomarker tests for detecting the cancer. This is a major event in the advancement of gastric cancer care, with the feasibility of rolling out the test in primary care in the near future.

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