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Prof Lawrence Ho Khek-Yu

Photo of Prof Lawrence Ho Khek-Yu


  • Senior Consultant, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital
  • Senior Consultant, National University Cancer Institute, Singapore
  • Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore


MBBS (Hons 1, Syd), MD (NUS), FRACP, FRCP (Glas), FAMS (Gastroenterology)



Clinical Disciplines/Programmes:

Gastroenterology & Hepatology, Medicine

Special Interests:

GI Oncology, Image-Enhanced Endoscopy (EUS, Confocal), Therapeutic Endoscopy (ERCP, Stenting, ESD), Functional GI disorders (GERD, BE), Stem Cell Therapy for Gastrointestinal Inflammatory Conditions and Associated Cancer, Innovative Endoscopy, including Confocal Endomicroscopy, EUS, Raman spectroscopy, Robotic Endoscopy, Cost Effectiveness


Professor Lawrence Khek-Yu Ho graduated with first-class honours from the University of Sydney, and undertook his training in therapeutic gastrointestinal endoscopy and endoscopic ultrasound at the Brigham and Women's Hospital, and Hospital of the University of Pennsylvania, USA. Besides being an accomplished endoscopist who has been invited to perform live case demonstrations in numerous international endoscopy workshops, he is an international key opinion leader in endoscopy. He was conferred the honorary International Life Membership of the Society of Gastrointestinal Endoscopy of India, and made Fellow of Japan Gastroenterological Endoscopy Society, to recognize his significant contributions to the field of gastrointestinal endoscopy. He is an effective educator, winning the Faculty Teaching Excellence Awards, National University of Singapore, in 2000 and 2003 respectively. He chairs the Asian Endoscopic Ultrasound Group, which is a well-established platform for leading EUS experts to promote endoscopic ultrasound training.

Experienced in spearheading collaboration between researchers in Asia, he co-chairs the Gut & Obesity in Asia (“Go Asia”) Workgroup, which aims to study the relationship between obesity and gastrointestinal and liver conditions in Asia. He also co-chairs and the USA NIH-NCS initiated Asian Barrett’s Consortium, bringing together Asian experts in gastroesophageal reflux disease to conduct research in Barrett’s esophagus. His regional standing as an academic leader is evident in the number of named lectures he has delivered in the region: as an orator at the Francisco Roman Memorial Lecture (Philippine Society of Gastroenterology and Philippine Society of Digestive Endoscopy, twice in 2003 & 2013 respectively), Nihal Marcus Memorial Oration (Sri Lanka Gastroenterological Association, 2012), and the Macau Society of Digestive Endoscopy Lecture (2013). In 2010, he was conferred the Journal of Gastroenterology and Hepatology Foundation Emerging Leadership lecturer at Asia Pacific Digestive Week. His editorial experiences include serving as Associate Editors of Techniques and Innovations in Gastrointestinal Endoscopy (officially affiliated with the American Gastroenterological Association), Digestive Diseases, Journal of Gastroenterology and Hepatology Open, and Digestive Endoscopy.

A proven clinician innovator and experienced entrepreneur, he co-invented the ground-breaking technology of the Master and Slave Transluminal Endoscopic Robot (MASTER), which has since been spun-off into the start-up, Endomaster. Endomaster became the 2017 Asia’s Best funded MedTech start-up. He also founded two other start-up companies, Endofotonics, a molecular AI based realtime diagnostic system, and Endopil, an ingestible weight loss balloon capsule. He received the Singapore President’s Technology Award in 2012, the highest honour bestowed on exceptional research scientists and engineers in Singapore for their excellent achievements in science and technology. He has published more than 260 peer-reviewed papers (H index Google Scholar, 59), more than 15 book chapters, co-edited 2 books, and held 10 granted patents in translational products.

He is the immediate past Vice Dean, School of Medicine, National University of Singapore. He is also past Head, Department of Medicine, National University of Singapore. He was President of Gastroenterological Society of Singapore in 2005. In recognition of his outstanding contributions to the medical profession, he was awarded the prestigious Distinguished Senior Clinician award. He was conferred the Public Administration Medal (Bronze) in 2017. He is currently the Director for the Centre for Innovation in Healthcare and the Director of NUH Referral Laboratory.


  • 2017 - Public Administration Medal
  • 2018 - Distinguished Senior Clinician Award

Journals & Publications

  1. Ho KY, Kang JY, Seow A. Prevalence of gastrointestinal symptoms in a multi-racial Asian population, with particular reference to reflux-type symptoms. American Journal of Gastroenterology 1998; 93: 1816-22.
  2. Song GH, Leng PH, Gwee KA, Moochhala SM, Ho KY. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances ─ a randomized double blind placebo controlled study. Gut 2005; 54: 1402-7.
  3. IS Ganpathi, JBY So, KY Ho. Endoscopic ultrasonography for gastric cancer. Surgical Endoscopy And Other Interventional Techniques 2006; 20 (4), 559-562.
  4. Ho KY, Phee SJ, Shabbir A, Low SC, Huynh VA, Kencana AP, Yang K , Lomanto D, So BKJ , Wong JYY, Chung SCS. Endoscopic Submucosal Dissection of Gastric Lesions Using a Master And Slave Transluminal Endoscopic Robot (MASTER). Gastrointest Endosc. 2010 Sep;72(3):593-9.
  5. Wang X, Ouyang H, Yamamoto Y, Kumar PA, Wei TS, Dagher R, Vincent M, Lu X, Bellizzi AM, Ho KY, Crum CP, Xian W, McKeon F. Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia. Cell. 2011 Jun 24;145(7):1023-35.
  6. Phee SJ, Reddy DN, Chiu PW, Pradeep R, Rao GV, Wang Z, Sun Z, Wong JY, Ho KY. Robot-Assisted Endoscopic Submucosal Dissection is Effective in Treating Patients with Early-Stage Gastric Neoplasia. Clin Gastroenterol Hepatol. 2012 Oct;10(10):1117-21.
  7. Xian W, McKean F, Ho KY. Biomarkers and Molecular Imaging in GI cancers. Clin Gastroenterol Hepatol. 2014 Jan;12(1):126-9.
  8. X Wang, Y Yamamoto, LH Wilson, T Zhang, BE Howitt, MA Farrow, F Kern, ...KY Ho, .... Cloning and variation of ground state intestinal stem cells. Nature 2015; 522 (7555), 173-178
  9. SK Teh, W Zheng, KY Ho, M Teh, KG Yeoh, Z Huang. Diagnostic potential of near-infrared Raman spectroscopy in the stomach: differentiating dysplasia from normal tissue. British journal of cancer 2008; 98 (2), 457-465
  10. Bergholt MS, Zheng W, Ho KY, Teh M, Yeoh KG, So JBK, Shabbir A, Huang ZW. Fiber-optic confocal Raman spectroscopy for real-time in vivo diagnosis of dysplasia in Barrett's esophagus. Gastroenterology. 2014 Jan;146(1):27-32.

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