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Prof Jimmy So

  • Head & Senior Consultant, Division of General Surgery (Upper Gastrointestinal Surgery), Department of Surgery, National University Hospital
  • Head & Senior Consultant, Division of Surgical Oncology, National University Cancer Institute, Singapore
  • Professor, Yong Loo Lin School of Medicine, National University of Singapore
  • Associate Director (Tumour Groups), National University Cancer Institute, Singapore
Surgery, Surgical Oncology
Bariatric & Metabolic Surgery, General Surgery, Surgical Oncology (Upper Gastrointestinal Surgery), Upper Gastrointestinal Surgery
Special Interests:
Surgical Oncology and Minimal Invasive Surgery for Gastric and Esophageal Cancer, Bariatric Surgery for Morbid Obesity and Metabolic Syndrome, Surgery for Gastroesophageal Reflux, Peroral Endoscopic Myotomy for Achalasia, Peritoneal Carcinomatosis, PIPAC and Intraperitoneal Chemotherapy


Prof Jimmy So graduated from Faculty of Medicine at the Chinese University of Hong Kong in 1991. He received his surgical training in National University Hospital, Singapore. He was trained in Upper Gastrointestinal Surgery, Surgical Oncology, Bariatric Surgery, Therapeutic Endoscopy and Minimally Invasive Surgery. He received fellowship training at Massachusetts General Hospital, Harvard Medical School, USA. He was also appointed as visiting consultant surgeon in Esophageal and Gastric Surgery at the Royal Infirmary in Edinburgh, Scotland, UK. He established a multidisciplinary program for Esophageal and Gastric cancers in NUH in 2005. He also received fellowship training in gastric and esophageal cancer surgery in Japan, Korea and Hong Kong. He is the pioneer in endoscopic surgery for early esophageal and gastric cancers, robotic surgery and Peroral Endoscopic Myotomy (POEM) for Achalasia in Singapore.

Prof Jimmy So’s special interests are in gastric cancer, esophageal cancer and obesity. He has published more than 140 peer reviewed scientific papers and received many research grants for his research work in these areas. He received a Gold Award at the annual scientific meeting of the National Healthcare Group. He was invited regularly to speak at International Gastric Cancer Congress, Annual Scientific Meetings of Japanese Gastric Cancer Association and Korean International Gastric Cancer Week. He has also presented his works at American Gastroenterological Association (AGA), American Society of Gastrointestinal Endoscopy (ASGE), Society of American Gastrointestinal Endoscopic Surgeons (SAGES), and World Congress of Endoscopic Surgery.

He is founding president of the Asia-Pacific Gastro-esophageal Cancer Congress in 2006. In 2013, he was the council member of the Consensus Meeting at the 10th International Gastric Cancer Congress, held at Verona, Italy. He is also a founding member of Asia-Pacific Bariatric Surgery Society. Prof So is a member of editorial board of medical journals such as Gastric Cancer, Journal of Gastric Cancer and Translational Medicine. He is a reviewer for a number of prestigious medical journals including New England Journal of Medicine, British Journal of Surgery, Annals of Surgical Oncology, Surgical Endoscopy and Digestive Disease and Science. Presently, he is actively involved in management of patients with gastric and esophageal cancers, morbid obesity and other Upper GI disorders.

Professional Highlights
Chairman, Organising Committee, Asia-Pacific Gastric Cancer Congress in 2006, 2012
Chairman, Organising Committee, GIST Tour 2011
Chairman, Organising Committee, Gastric Cancer Awareness Month, Singapore Cancer Society
Executive Committee, Singapore Gastric Cancer Consortium (SGCC)


  • 2020 - Laureate of the Peritoneum Prize
  • 2018 - Yahya Cohen Memorial Lectureship by College of Surgeons Singapore

Journals & Publications

  1. Association of metabolic-bariatric surgery with long-term survival in obese adults with and without diabetes: a patient-level meta-analysis of 174,772 participants with 1·2 million patient-years of follow-up. Nicholas L. Syn; Zong Jie Koh, Claire Chew, Lin J. Daryl, Joseph J. Zhao; Louis Z. Wang, Ying Ern Loo; Bee Choo Tai, Guo Wei Kim; Jimmy BY So, Lee M. Kaplan, MD PhD; David E. Cummings, John B. Dixon, Asim Shabbir. The Lancet. Published online May 6, 2021
  2. Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair.
    Matsuo J, Douchi D, Myint K, Mon NN, Yamamura A, Kohu K, Heng DL, Chen S, Mawan NA, Nuttonmanit N, Li Y, Srivastava S, Ho SWT, Lee NYS, Lee HK, Adachi M, Tamura A, Chen J, Yang H, Teh M, So JB, Yong WP, Tan P, Yeoh KG, Chuang LSH, Tsukita S, Ito Y. Gut. 2020 Dec 8 : gutjnl-2020-322779. doi: 10.1136/gutjnl-2020-322779. Epub ahead of print. PMID: 33293280.
  3. Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicentre randomised controlled trial.
    Yang HK, Ji J, Han SU, Terashima M, Li G, Kim HH, Law S, Shabbir A, Song KY, Hyung WJ, Kosai NR, Kono K, Misawa K, Yabusaki H, Kinoshita T, Lau PC, Kim YW, Rao JR, Ng E, Yamada T, Yoshida K, Park DJ, Tai BC, So JBY.
    Lancet Gastroenterol Hepatol. 2020 Nov 27 : S2468-1253(20)30315-0. doi: 10.1016/S2468-1253(20)30315-0. Epub ahead of print. PMID: 33253659.
  4. PIPAC-OX: A Phase I study of Oxaliplatin-based Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients with Peritoneal Metastases
    Kim G, Tan HL, Sundar R, Lieske B, Chee CE, Ho J, Shabbir A, Babak MV, Ang WH, Goh BC, Yong WP, Wang L, So JBY.
    Clin Cancer Res. 2020 Nov 4:clincanres.2152.2020. doi: 10.1158/1078-0432.CCR-20-2152.  Epub ahead of print. PMID: 33148667.
  5. DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia
    Krishnan V, Lim DXE, Hoang PM, Srivastava S, Matsuo J, Huang KK, Zhu F, Ho KY, So JBY, Khor C, Tsao S, Teh M, Fock KM, Ang TL, Jeyasekharan AD, Tan P, Yeoh KG, Ito Y.  Gut. 2020 Oct;69(10):1738-1749. doi: 10.1136/gutjnl-2019-319002. Epub 2020 Jan 14.  PMID: 31937549; PMCID: PMC7497583.
  6. Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population
    So JBY, Kapoor R, Zhu F, Koh C, Zhou L, Zou R, Tang YC, Goo PCK, Rha SY, Chung HC, Yoong J, Yap CT, Rao J, Chia CK, Tsao S, Shabbir A, Lee J, Lam KP, Hartman M, Yong WP, Too HP, Yeoh KG. Gut. 2020 Oct 7:gutjnl-2020-322065. doi: 10.1136/gutjnl-2020-322065. PMID: 33028667.
  7. AQP5 enriches for stem cells and cancer origins in the distal stomach.
    Tan SH, Swathi Y, Tan S, Goh J, Seishima R, Murakami K, Oshima M, Tsuji T, Phuah P, Tan LT, Wong E, Fatehullah A, Sheng T, Ho SWT, Grabsch HI, Srivastava S, Teh M, Denil SLIJ, Mustafah S, Tan P, Shabbir A, So J, Yeoh KG, Barker N.
    Nature. 2020 Feb;578(7795):437-443. doi: 10.1038/s41586-020-1973-x.
  8. Pouch reconstruction after total gastrectomy: a meta-analysis. Syn N, Wee I, Kim GW, Shabbir A, So JB. Annals of Surgery 2018, 269 (6), 1041-1053.
  9. Roux-en-Y or Billroth II Reconstruction After Radical Distal Gastrectomy for Gastric Cancer: A Multicenter Randomized Controlled Trial. So JB, Rao J, Wong AS, Chan YH, Pang NQ, Tay AY, Yung MY, Su Z, Phua JN, Shabbir A, Ng EK. Annals of Surgery. 2017, 267 (2), 236-242.
  10. Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer.
    Huang KK; Ramnarayanan K; Zhu F; Srivastava S; Xu C; Tan ALK; Lee M; Tay S; Das K; Xing M; Fatehullah A; Alkaff SM F; Lim TK H; Lee J; Ho KY; Rozen SG; Teh BT; Barker N; Chia CK; Khor C; Ooi CJ; Fock KM; So J; Lim WC; Ling KL; Ang TL; Wong A; Rao J; Rajnakova A; Lim LG; Yap WM; Teh M; Yeoh KG; Tan P
    Cancer Cell, 2018 Jan;33(1), 137-+. doi:10.1016/j.ccell.2017.11.018
    PMID: 29290541 (IF: 23.92)

Professional Memberships

  • American Society of Gastrointestinal Endoscopy (ASGE)
  • Society of American Gastrointestinal & Endoscopic Surgeons (SAGES)
  • International Gastric Cancer Association (IGCA)
  • Society of Surgery for Alimentary Tract
  • International Society of Diseases of Esophagus (ISDE)


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