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Research Facilities

NUHS offers a wide range of research facilities and services which provide access to state-of-the-art instrumentation and cutting edge technology to facilitate and enhance basic, clinical and translational research conducted by our researchers and students. Several of the research facilities also provide training and support services to assist investigators to make optimal use of the advanced technologies available to them. Highly-trained staff offer assistance at various stages of a project such as developing research proposals, sample preparation to analyzing, processing, and interpreting the data that are generated by sophisticated technologies. Find out more below.

BSL3

Introduction

Research and diagnosis of risk group 3 (RG3) biological agents require specially designed biocontainment areas and operating procedures to ensure the safety of operators, researchers and communities. Established in November 2014 at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), the Biosafety Level-3 (BSL-3) Core Facility is the largest research-focused biocontainment facility in Singapore. The facility supports research and diagnostic work involving a range of RG3 pathogens. It is certified by the Biosafety Branch of the Singapore Ministry of Health and the Agri-Food & Veterinary Authority of Singapore.

Situated in the Centre for Translational Medicine (MD6) on the NUS Kent Ridge campus, the state-of-the-art 650 m2 space is equipped with both essential and complex laboratory equipment (including flow cytometers, spectrophotometers and an aerosolization machine for establishing infectious disease mouse models). Associate Professor Justin Chu Jang Hann serves as the head of the BSL-3 Core Facility, directing a team of skilled personnel who operate the facility as well as assist in performing in vitro and in vivo work with RG3 pathogens. Currently, the facility is regularly used by more than 40 researchers, from NUS and other institutions, to conduct their research on RG3 biological agents. It also supports National Public Health Laboratory activities such as RG3 pathogen surveillance and national preparedness for effective outbreak management.

Web: http://nusmedicine.nus.edu.sg/research/biosafety-level-3-laboratory-bsl-3

Contact: 
Ms. Sindhu Ravindran (Senior Manager & Biosafety Coordinator)
+65-66011020
sindhu_ravindran@nuhs.edu.sg

CHSPR

Introduction

Health Services and Policy Research is a multidisciplinary field of scientific investigation that asks:
What works for whom, at what cost, and under which circumstances?

The Centre for Health Services and Policy Research (CHSPR) was established in April 2014 as a Centre for organising health services to meet the health needs of a population. The Centre studies how social factors, financing systems, organisational structures and processes, health technologies, and personal behaviour affect access to healthcare, the quality and cost of healthcare, and ultimately our health and well-being, through a systems-level approach. It aims to tackle healthcare issues from a multidisciplinary perspective, connecting healthcare workers, patients, researchers, policy- and decision-makers in the fast-changing nature of health services delivery. It also aims to conduct research into the use of data analytics to improve clinical care delivery and patient safety.

The Centre envisions to position the National University Health Systems to be a strategic partner to the Ministry of Health and the Agency for Integrated Care, and a strong player in the region to conduct Health Systems Research for informing policies and clinical practices.

Web: http://blog.nus.edu.sg/chspr/

Contact: 
Toh Kai Yee
+65-65165782 
chspr_admin@nus.edu.sg

CPPH

Introduction

The Centre for Personalized and Precision Health (CPPH) was set up in late 2014 to form the core for research in personalized and precision health in NUHS. CPPH believes that the future of medicine lies in the stratification of patients based on their health conditions, their needs, or the biology of the disease, and followed by the delivery of the care which maximize health and cost-effectiveness while limiting toxicity and other adverse effects.

Through exploiting characteristics unique to Asian phenotypes for targeted diagnosis and treatment, by bringing together –omics analysis, bioinformatics, health services research, patient data analytics and clinical trials, CPPH targets to develop new methods of disease management and evaluation of effectiveness against the MOH’s five strategic areas of diseases, namely cancers, cardiovascular diseases, diabetes mellitus and other metabolic / endocrine conditions, infectious diseases and neurological and sense disorders.

CPPH is chiefly responsible for developing the strategy for precision medicine in NUHS and serves as the contact point for precision medicine efforts at the national level and with other industry players. The core objectives of CPPH is to strengthen strategic alliances with industry partners to implement precision medicine in NUHS and to provide advice for project management and administrative support for pilots leading to clinical implementation in specific disease areas where precision medicine may have an impact in the short term.

Contacts: 
Professor Tai E Shyong (Director)
mdctes@nus.edu.sg 

Ms. Mun Le Xuan (Administrator)
le_xuan_mun@nuhs.edu.sg

CIRC

Introduction

Established by the Agency for Science, Technology and Research (A*STAR) and the National University of Singapore (NUS), the Clinical Imaging Research Centre (CIRC) has become an integral part of Singapore’s clinical and translational research landscape.

A multidisciplinary and multinational centre with state-of the-art facilities, CIRC is a national resource for clinical research and training. The team of dedicated and passionate researchers works synergistically and performs diverse clinical research studies with a key focus on diseases which are of particular relevance to Singapore’s population and medical landscape Highly integrative and collaborative, the Centre works with both private and public institutions across Singapore as well as international partners in academic and industrial fields. From advanced imaging to the development and production of radiopharmaceuticals for pre-clinical and human use, the Centre cultivates translational research across Singapore.
In addition, CIRC’s training programmes and courses help nurture clinicians and scientists and prepare them for a future career in research.

Web: https://www.circ.nus.edu.sg/index.php

Contact: 
Nguang Hock Soon Bernard, Senior Manager
circenquiries@nus.edu.sg

Confocal Microscopy Unit

Introduction

Our mission is to serve as an enabler in translational research by offering affordable and efficient access to standard and advanced imaging instrumentation for users of all levels of experience and from any discipline. We also strive in providing a one-stop service solution ranging from experimental design, full sample preparation, new protocol development, image acquisition, to scalable image processing, big data image-based data analytics and multi-dimensional visualisation.

Confocal Microscopy Unit provides an extensive range of capabilities:

  • Conventional Confocal and Brightfield imaging
  • Stable Live-cell time-lapse imaging
  • 3D imaging
  • F-techniques (i.e. FRAP, FRET)
  • Fluorescence and Histology slide scanning
  • Total Internal Reflection Fluorescence (TIRF)
  • Phase confocal for biophysical measurements (under development)
  • Full sample preparation (cell isolation from small rodents, cell culture, and reagent preparation to most experiments before imaging)
  • Relevant reagent and protocol such as secondary antibodies are provided at cost to enable sample preparation on site.
  • Big data image processing and machine-learning based data analytics
  • On site training facilities and expertise to ensure a novice user can be guided to perform the right experiments and obtain the desired results all in one place.

We welcome both internal and external users.
Please contact a member of our staff for inquiries.

Contacts: 
Prof. Hanry Yu (Director)
medyuh@nus.edu.sg 

Ms. Lee Shu Ying (Senior Lab Executive)
medleesy@nus.edu.sg 

Ms. Sylvia Chew Yu Ting (Lab Executive)
medscyt@nus.edu.sg 

+65-65166306

EMU

Introduction

The Electron Microscopy Unit is a central facility in Yong Loo Lin School of Medicine, National University of Singapore, housing four Transmission Electron Microscopes (TEMs), two Scanning Electron Microscopes (SEMs), and sample preparation facilities. Our mission is to provide high quality EM solutions for biomedical researchers in the Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, and the scientific community.
Staff in the EM Unit conduct in-house training in EM usage, and ensure that equipment are in working condition, and the laboratory is a safe and comfortable place to work in.

Contact: 
Prof Ong Wei Yi (Director)
+65-65163662
wei_yi_ong@nuhs.edu.sg

Flow
Introduction

Our mission is to offer updated infrastructure (relevant flow cytometers and other instrument) and serve as a one stop service solution to users’ requirements relevant to experimental design, sample preparation, new protocol development, professional flow cytometer template set up and data acquisition, as well as high throughput data processing and analysis.

We deliver high quality flow cytometry workshop/courses, discussion forum as well as a platform for clinician scientists, residents, graduate students, medical students and researchers to establish collaborations.

Flow cytometry is a technology used to analyse the physical and chemical characteristics of particles in a fluid as it passes through one or more laser(s).

The core offers state-of-art flow cytometry analysis and high-speed sorting to research community in NUS and NUHS

We are currently equipped with:

  • Beckman Coulter MoFlo Astrios Cell Sorter which comes with four lasers (15 Colors) and is capable of 6 way sorting.
  • BD LSR Fortessa with four lasers (16 colors) and
  • Beckman Coulter CyAn ADP with three lasers (9 colors).

We provide comprehensive training to users in Singapore all on one site.

We also provide advanced training for operators of core facilities in South East Asia, in collaboration with industry partners.

We welcome both internal and external users.
Please do not hesitate to contact us for further inquiries.

Contacts: 
Prof. Hanry Yu (Director)
medyuh@nus.edu.sg
+65-65166306 

Ms. Wang Xiaoning (Senior Lab Executive)
medwx@nus.edu.sg 

Mr. Toh Chin Min (Lab Executive)
medtcm@nus.edu.sg 

IMU

Introduction

The Investigational Medicine Unit (IMU) was established to lead and facilitate investigational medicine research within NUHS through collaborations with academics and industry partners to translate laboratory discoveries.
It facilitates and conducts high quality clinical trials to enable patient access to novel therapeutics and technology. IMU's focus is on early phase clinical trials which includes Proof of Concept, Phase 1 and Phase 2a studies for novel drugs and devices. It also supports late phase studies, biomarker research as well as bio-imaging analysis.

Web: https://imu.nus.edu.sg/

Contact: 
Lin Yuchen
+65-66012543
yuchen_lin@nuhs.edu.sg

Phenotyping

Introduction

The Metabolic Core provides metabolic phenotyping services that are essential in both cross-sectional and prospective studies. These services include oral and intravenous glucose tolerance tests, glucagon stimulation tests, euglycemic and hyperglycemic clamp studies, and indirect calorimetry. We collaborate with other research partners to facilitate cold stimulation studies and imaging for brown adipose tissue, as well as tracer infusion studies for hepatic glucose production. The Metabolic Core has also established percutaneous skeletal muscle biopsies and myocyte cultures for experiments involving skeletal muscle.

Our Staff

NameKey Responsibilities
Assistant Professor Khoo Chin Meng (Core Director)
Senior Consultant, 
Department of Medicine
Dr Khoo Chin Meng is a Senior Consultant endocrinologist in the Department of Medicine at the National University Hospital (NUH), Singapore, and Assistant Professor in the National University of Singapore Yong Loo Lin School of Medicine. His research interests are in the pathogenesis of type 2 diabetes mellitus and obesity/metabolic disorders. He works with partners from NUS and other academic institutions, and with pharmaceutical partners in developing and executing research protocols.
Sandi Myo ThantSandi joined the team in 2013 and has since been executing clinical procedure support for various studies, showing exceptional skills in intravenous cannulation. With her well-versed medical background, she took on the additional role of performing laboratory procedures such as PBMC isolation and ELISAs.
Kyaw Myo Thant TinoTino joined the team in 2013 and has coordinated many research studies over the years. He is in charge of administrative functions, including procurement, inventory check, and adherence to institutional regulations and compliance requirements. He is in charge of conducting venepuncture/cannulation training, and has also shown impressive skills in performing clinical studies.
Lui Kai FooMr Lui possesses outstanding technical skill sets, which he employs in ensuring proper maintenance of clinical equipment. His 20+ years’ experience is reflected in the high quality of the clinical data obtained in his research studies.
Toh Koh JongKoh Jong is in charge of equipment maintenance, in adherence to audit requirements. She has been working to maintain the specimen repository, ensuring proper biobanking of samples for future collaborations. She is responsible for training researchers in calibration and maintenance of the glucose analyzers in the core.
Jayagowtham K AnnaduraiWith a biomedical science background and past wet-lab experience, Jayagowtham has shown great potential in the research field. He provides clinical support during procedures, and has also taken on additional roles such as sample processing. Moreover, he provides administrative support in the form of maintaining documents, adhering to research and safety protocols in the process.

Menu of Services

TestPrice (Academic)Price (Non-Academic)
Oral Glucose Tolerance Test (OGTT)$154.66$231.99
Intravenous Glucose Tolerance Test (IVGTT)$459.69$689.54
Mixed Meal Tolerance Test (MMTT)$180.07$270.11
Hyperinsulinemic Euglycemic Clamp Studies$4765.44$1,148.15
Human in vitro cultures of Muscle and Fat$348.59$522.89
Indirect Calorimetry / Energy Expenditure Test$86.13$129.20

Note: “Prices listed are subject to revision, based on periodic cost review”

Contacts: 
Mr. Tino Kyaw Myo Thant 
mdckmt@nus.edu.sg 

Ms. Sandi Myo Thant 
mdcsmt@nus.edu.sg

Phenotyping

 Introduction

The Neuroscience Phenotyping Core at NUS offers equipment and expertise to analyze neurobehavioural functions. Investigators have a broad range of assays to choose from. These assays can be further customized to their specific interests.
In addition to these resources, the Neuroscience Phenotyping Core provides training and consultation services including advice on study feasibility, experimental design, data analysis and interpretation.

Web: http://neurophenocore.nus.edu.sg/

Contact: 
Dr Wong Peiyan
phcwp@nus.edu.sg

MACC

Introduction

With a rapidly ageing population in Singapore, the prevalence of dementia is expected to increase to 53,000 by 2020 and to further increase to 187,000 by 2050. The MACC aims to develop novel scientific insights and advances in the understanding of dementia and cognitive impairment leading to interventions that can prolong independent community function, delay institutionalization and therefore lower healthcare expenditure for patients suffering from dementia. The MACC has been supported by a Centre Grant(CG) from the NMRC since 2010.

MACC owns a team experienced clinicians, psychometric raters and research coordinators, who have the expertise to design, initiate and carry out complex studies and clinical drug trials in multi-ethnic cognitive impaired or demented population.

The MACC research facilities – the MACC Assessment unit is equipped with comfortable assessment rooms with tools, devices & equipment for the conduct of various assessments ranging from clinical, neuropsychological and retinal eye imaging. MACC’s full BSL2 laboratory is located in MD 6. We have an active collaboration with CIRC for its 3T MRI facilities and PET Imaging.

Web: https://www.nuhs.edu.sg/research/MACC/Pages/About-Us.aspx

Contact: 
Connie Teo Kee Ling
+65-66015668
Kee_ling_teo@nuhs.edu.sg

TECT

Introduction

Tissue Engineering and Cellular Therapy (TECT) Lab was commissioned in 2012. The lab was approved as a GMP compliant lab by the Health Sciences Authority in 2015. The facility is under the management of the National University Cancer Institute, Singapore (NCIS) and it supports the Immunocellular therapy (ICT ) that covers both immunotherapy (for cancer treatment) and regenerative medicine (tissue repair). The TECT provide clinical services such as mesenchymal stem cell therapy for graft versus host disease and natural killer cell therapy for high risk acute lymphoblastic leukaemia.

TECT serves a platform to incorporate clinicians, researchers and technologists facilitating the translation of benchtop findings via technical transfer into validated procedures and clinical trials. The facility comprises of certified cleanrooms with capabilities that include flow cytometry and cell selection. 

Contacts: 
Dr Tan Lip Kun (Medical Director) 
+65-67724179 
lip_kun_tan@nuhs.edu.sg 

Dr Yap Eng Soo (Assistant Medical Director)
+65-67726204 
Eng_Soo_Yap@nuhs.edu.sg 

Soh Teck Guan (Laboratory Director) 
+65-67725398 
teck_guan_soh@nuhs.edu.sg

TR

Introduction

The NUH Tissue Repository (TR) is a well-established core facility with infrastructure in bio-banking and data collection. Its mission is to provide investigators with high quality clinical samples and associated data in a manner that is safe, efficient and ethical. TR ensures the harvesting, processing and storage of bio-specimens is in accordance with national legislation (PDPA, HBRA) and international best practices laid out by International Society for Biological and Environmental Repositories (ISBER), a leading global organization that promotes and harmonize high quality standards, ethical principles and innovation in the science and management of bio-repositories. TR provides a platform for investigators to access bio-specimen related research and bio-banking resource management services at a fee for service. TR freezer farms at offsite warehouses provide solution in business continuity planning, addressing unforeseen events such as natural or man-made disasters or equipment failure that may render parts or all of inventories unusable. TR’s high throughput automated liquid handler for processing liquid bio-specimen enables TR to support large scale multi-centres projects in bio-banking. These are all made possible through the support of a core of multidisciplinary team in consent taking, bio-specimen accrual, processing, quality control, storage, retrieval, distribution, annotation of associated data and management.

Web: http://medicine.nus.edu.sg/tissue/

Contact: 
Dr Eng Chon Boon (Director)
+65-67722379
chon_boon_eng@nuhs.edu.sg