Adj A/Prof Vitaly A Sorokin

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2024/03/11

Adj A/Prof Vitaly A. Sorokin

Designations:

Senior Consultant, Adult Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore
Adjunct Associate Professor, Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore

Qualifications:

MD (Russia), MRCS (Edin), FRCS CTh (Edin), PhD

Specialties/Sub-specialties:

Cardiothoracic Surgery

Clinical Disciplines/Programmes:

Adult Cardiac Surgery, Aortic Surgery, Cardiothoracic Surgery (Heart), Minimally Invasive Cardiac Surgery

Special Interests:

Aortic Arch and Aortic Dissection Surgery, Aortic Valve and Aortic Root Surgery, Aortic Valve Repair, Thoracoabdominal Aortic Surgery,

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www.nuhcs.com.sg/

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Biosketch

Adj A/Prof Vitaly A. Sorokin is presently a Senior Consultant with the Department of Cardiac, Thoracic and Vascular Surgery (CTVS) at National University Heart Centre, Singapore (NUHCS). He is also an Adjunct Associate Professor with the Department of Surgery at Yong Loo Lin School of Medicine, National University of Singapore since 2009 as well as a Visiting Professor to the Russian State Medical University since 2010.

He received MD in 1995 in USSR, defended his thesis and obtained PhD degree in 1999. As a cardiac surgeon, he came to Singapore in 2004 and spent five years to obtain the Singapore board certification in 2010 after completing the advance surgical training program in cardio-thoracic surgery. Follow successful examination at Royal College of Surgeon of Edinburgh (FRCS CTh Edin), he spent one year in Dusseldorf, Germany to sub-specialize as an aortic and minimally invasive cardiac surgeon. Currently, Adj A/Prof Vitaly is the Director of the Aortic Centre Programme at NUHCS and the Research Director of Department of CTVS.

Clinical care from his activities as a cardiac surgeon is increasingly focused on the highly specialized area of cardiac surgery - aortic surgery. It includes genetically-related aortic pathology like Marfan syndrome, Ehlers-Danlos syndrome and other connective tissue disorders. The significance and ultimate objective of his clinical specialization for this group of patients is to develop scientific approaches and solutions to treat deficient connective tissues. Surgical approach is the only available solution currently and is unfortunately highly risky for patients. Understanding the alteration of connective tissue differentiation, apoptosis and growth grants us the opportunity to explore the deficient biological network in disease progression and development of complications. Multi-omic approaches with the investigation of genome, transcriptome and proteome components of the aortic wall would give us information in connective tissue disorders. The discovered tissue network and markers would be investigated for parallel changes in the patients' plasma, which is easily available for clinical screening.

Combining clinical service for aortic disease patients with strong research program is the main objective driving Adj A/Prof Vitaly's enthusiasm to develop new clinical service in NUH - National University Aortic Program, which will be unique not only in Singapore, but also in South-East Asia.

Awards

NUS Resilience and Growth Postdoctoral Fellowship, “Human Arterial Single Cell NGS to Evaluate VSMC Plasticity”, $185,581.44, May 2021-May 2023 (2 years)
Lee Foundation Singapore Research & Education, “Single Cell Microfluidic Platform for Cardiovascular Disease”, $1,800,000, Aug 2020-Aug 2023 (3 years)
NUHS Joint Grant Call - MOE AcRF Tier 1, “Vascular smooth muscle genes modulation to control atherosclerosis progression”, $179,900, Mar 2018-Mar 2021 (3 years)
NUHS Bridging Funds, “Differential Gene Expression of Aortic Wall Tissue from Patients with Low Syntax Score and High Syntax Score: A Class Comparison Study to Investigate the Genomic Regulation of Different Pattern of Coronary Lesions”, $75,000, Nov 2017-Oct 2018 (1 year)
NHIC-I2P Grant, “The Use Of Protein Signature For Diagnosis Of Myocardial Injury”, $5,000, Feb-Jul 2017 (6 months)
NUHS-NHIC Joint MedTech Grant, “Development of medical technology to use plasma biomarker assay platform for non-invasive diagnose of early stage coronary artery disease”, $50,000, Nov 2016-Oct 2017 (1 year)
NUS Cross-Faculty Grant, “Coronary Angiogram as a tool to estimate flow in coronary bypass and choose appropriate graft”, $25,000, Feb 2016-Feb 2018 (2 years)

Journals & Publications

1. Sule J, Chua CR, Teo C, Choong A, Sazzad F, Kofidis T, Sorokin V. Hybrid type II and frozen elephant trunk in acute Stanford type A aortic dissections. Scand Cardiovasc J. 2022 Dec;56(1):91-99. doi: 10.1080/14017431.2022.2074095. PMID: 35546567.
2. Kumar P, Lim A, Poh SL, Hazirah SN, Chua CJH, Sutamam NB, Arkachaisri T, Yeo JG, Kofidis T, Sorokin V, Lam CSP, Richards AM, Albani S. Pro-Inflammatory Derangement of the Immuno-Interactome in Heart Failure. Front Immunol. 2022 Mar 15;13:817514. doi: 10.3389/fimmu.2022.817514. PMID: 35371099; PMCID: PMC8964981.
3. Czerny M, Gottardi R, Puiu P, Bernecker OY, Citro R, Della Corte A, di Marco L, Fink M, Gosslau Y, Haldenwang PL, Heijmen RH, Hugas-Mallorqui M, Iesu S, Jacobsen O, Jassar AS, Juraszek A, Kolowca M, Lepidi S, Marrocco-Trischitta MM, Matsuda H, Meisenbacher K, Micari A, Minatoya K, Park KH, Peterss S, Petrich M, Piffaretti G, Probst C, Reutersberg B, Rosati F, Schachner B, Schachner T, Sorokin VA, Szeberin Z, Szopinski P, Di Tommaso L, Trimarchi S, Verhoeven ELG, Vogt F, Voetsch A, Walter T, Weiss G, Yuan X, Benedetto F, De Bellis A, D Oria M, Discher P, Zierer A, Rylski B, van den Berg JC, Wyss TR, Bossone E, Schmidli J, Nienaber C; Collaborators, Accarino G, Baldascino F, Böckler D, Corazzari C, D Alessio I, de Beaufort H, De Troia C, Dumfarth J, Galbiati D, Gorgatti F, Hagl C, Hamiko M, Huber F, Hyhlik-Duerr A, Ianelli G, Iesu I, Jung JC, Kainz FM, Katsargyris A, Koter S, Kusmierczyk M, Kolsut P, Lengyel B, Lomazzi C, Muneretto C, Nava G, Nolte T, Pacini D, Pleban E, Rychla M, Sakamoto K, Shijo T, Yokawa K, Siepe M, Sirch J, Strauch J, Sule JA, Tobler EL, Walter C, Weigang E. Impact of the coronavirus disease 2019 (COVID-19) pandemic on the care of patients with acute and chronic aortic conditions. Eur J Cardiothorac Surg. 2021 May 8;59(5):1096-1102. doi: 10.1093/ejcts/ezaa452. PMID: 33394040; PMCID: PMC7799089.
4. Park JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SC, Liou KCK, Lynn SE, Ng SS, Meng W, Lim SC, Leow MK, Richards AM, Pennington DJ, de Kleijn DPV, Sorokin V, Ho HH, McCarthy NE, Sze SK. Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Atherosclerosis. 2021 May 1;324:58-68. doi: 10.1016/j.atherosclerosis.2021.03.020. Epub 2021 Mar 24. PMID: 33831670.
5. Leow L, Qian Q, Chew KL, Sorokin V. Unusual presentation of Aspergillus aortitis after aortic valve surgery with massive hemoptysis. JTCVS Tech. 2021 Jan 6;6:63-65. doi: 10.1016/j.xjtc.2020.12.004. PMID: 34318144; PMCID: PMC8300912.
6. Papadimas E, Tan YK, Qi Q, Ng JJ, Kofidis T, Teoh K, Sorokin V, Choong AMTL. Left heart bypass versus circulatory arrest for open repair of thoracoabdominal aortic pathologies. ANZ J Surg. 2020 Dec;90(12):2434-2440. doi: 10.1111/ans.16287. Epub 2020 Sep 16. PMID: 32935430.
7. Sorokin V, Vickneson K, Kofidis T, Woo CC, Lin XY, Foo R, Shanahan CM. Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation. Front Immunol. 2020 Nov 26;11:599415. doi: 10.3389/fimmu.2020.599415. PMID: 33324416; PMCID: PMC7726011.
8. Koo CY, Aung AT, Chen Z, Kristanto W, Sim HW, Tam WW, Gochuico CF, Tan KA, Kang GS, Sorokin V, Ong PJL, Kojodjojo P, Richards AM, Tan HC, Kofidis T, Lee CH. Sleep apnoea and cardiovascular outcomes after coronary artery bypass grafting. Heart. 2020 Oct;106(19):1495-1502. doi: 10.1136/heartjnl-2019-316118. Epub 2020 May 18. PMID: 32423904.
9. Gurung R, Choong AM, Woo CC, Foo R, Sorokin V. Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm. Int J Mol Sci. 2020 Aug 31;21(17):E6334. doi: 10.3390/ijms21176334. PMID: 32878347.
10. Mehdiani A, Sorokin VA, Sule J, Smiris K, Stadnik D, Lichtenberg A, Blehm A. Mid-term single-centre outcomes of BioIntegral compared to Freestyle aortic conduit implantation. J Cardiovasc Surg (Torino). 2020 Aug;61(4):512-519. doi: 10.23736/S0021-9509.19.11098-1. Epub 2019 Dec 6. PMID: 31815376.

Professional Memberships

European Association of Cardiothoracic Surgery
Asian Society of Cardiovascular and Thoracic Surgery
Russian Society of Cardiovascular Surgery
The Society of Thoracic Surgeons

2024/06/11

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