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2024/03/11
Doctor Detail

Asst Prof Swaine Lin Chen

Photo of Asst Prof Swaine Lin Chen

Designations:

  • Senior Research Scientist, Division of Infectious Diseases, University Medicine Cluster, National University Hospital
  • Senior Research Scientist, Division of Infectious Diseases, Department of Medicine, National University of Singapore (NUS)
  • Senior Research Scientist, Genome Institute of Singapore, Infectious Diseases Group

Specialties/Sub-specialties:

Infectious Diseases

Clinical Disciplines/Programmes:

Medicine

Special Interests:

Uropathogenic E. coli, Bacterial genetics and genomics, Molecular evolution, Host-pathogen interactions

Find Out More:

Awards

Singapore National Research Foundation Fellow

Journals & Publications

1. Chen, S. L., C. S. Hung, J. S. Pinkner, J. N. Walker, C. K. Garofalo, Z. Li, J. Bouckaert, J. I. Gordon, and S. J. Hultgren (2009). "Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding." Proc Natl Acad Sci U S A 106(52):22439-44.
2. Chen, S. L.*, C. S. Hung*, J. Xu, C. S. Reigstad, V. Magrini, A. Sabo, D. Blasiar, T. Bieri, R. R. Meyer, P. Ozersky, J. R. Armstrong, R. S. Fulton, J. P. Latreille, J. Spieth, T. M. Hooton, E. R. Mardis, S. J. Hultgren, and J. I. Gordon (2006). "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach." Proc Natl Acad Sci U S A 103(15):5977-82.
3. Chen, S. L., W. Lee, A. K. Hottes, L. Shapiro, and H. H. McAdams (2004). "Codon usage between genome is constrained by genome-wide mutational processes." Proc Natl Acad Sci U S A 101(10):3480-5.
4. Chen, S. L. and L. Shapiro (2003). "Identification of long intergenic repeat sequences associated with DNA methylation sites in Caulobacter crescentus and other alpha-proteobacteria."
5. Laub, M. T.*, S. L. Chen*, L. Shapiro and H. H. McAdams (2002). "Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle." Proc Natl Acad Sci U S A 99(7): 4632-7.
6. Hadjifrangiskou, M., M. Kostakioti, S. L. Chen, J. P. Henderson, S. E. Greene, and S. J. Hultgren. "A Central Metabolomic Circuit Controlled by QseC in Pathogenic Bacteria." Submitted.
7. Cusumano, C. K., C. S. Hung, S. L. Chen, and S. J. Hultgren (2010). "Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis." Infect Immun 78(4):1457-67.
8. Chen, S. L., C. S. Hung, J. S. Pinkner, J. N. Walker, C. K. Garofalo, Z. Li, J. Bouckaert, J. I. Gordon, and S. J. Hultgren (2009). "Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding." Proc Natl Acad Sci U S A 106(52):22439-44.
9. Chen, S. L., S. L. Jackson, and E. J. Boyko (2009). "Diabetes mellitus and urinary tract infection: Epidemiology, Pathogenesis and Proposed Studies in Animal Models." Review article. J Urology 182(6):S51-6.
10. Giannakis, M.*, H. K. Backhed*, S. L. Chen*, J. J. Faith*, M. Wu, J. L. Guruge, L. Engstrand, J. I. Gordon (2009). "The response of gastric epithelial progenitors to Helicobacter pylori isolates obtained from Swedish patients with chronic atrophic gastritis." J Biol Chem 284(44):30383-94.

2024/05/02
1E Kent Ridge Road, NUHS Tower Block, Singapore 119228
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