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A/Prof Mark Chan Yan Yee

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  • Senior Consultant, Department of Cardiology, National University Heart Centre, Singapore
  • Associate Professor, Yong Loo Lin School of Medicine, National University of Singapore


MBBS (S'pore), MHS (USA), MMED (Int Med), MRCP (UK), PhD (Netherlands)



Clinical Disciplines/Programmes:

Cardiology (Heart), Interventional Cardiology

Special Interests:

Early phase mechanistic clinical trials of novel therapeutic compounds in coronary heart disease, Human-centric technological solutions to transitional care of acute coronary syndromes, Interventional cardiology – coronary interventions, Proteomics and lipidomics in coronary heart disease, Translational applications of metabolomics

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Dr Mark Chan, MBBS, PhD, is an Associate Professor at Yong Loo Lin School of Medicine, National University of Singapore (NUS) and Senior Consultant at the Department of Cardiology, National University Heart Centre, Singapore (NUHCS).

He is the Deputy Executive Director of NUHCS, Deputy Director of Cardiovascular Research Institute (CVRI), NUHCS, and the Deputy Director of the Cardiovascular Disease Translational Research Program, NUS, where he supervises translational research and clinical trials of acute myocardial infarction. He is also the Co-director of the Cardiovascular Summit Research Program (SRP), NUHS.

He leads the post-myocardial infarction clinic at NUHCS and the national Acute Myocardial Infarction: allied Health-Oriented, Patient-centred and technology-Enabled (AMI-HOPE) program with Singhealth and NHG colleagues. 

In 2019, he received the National Medical Research Council Clinician Scientist Senior Investigator Award.  He is overall PI of the 3-country randomized controlled trial of an anti-inflammatory small-molecule inhibitor to treat atherosclerosis in patients with AMI (PASSIvation of Vulnerable plaques with AZD5718 in acuTE coronary syndrome – the PASSIVATE trial) supported by a 10 million USD externally-sponsored from Astra-Zeneca.


  • National Medical Research Council Senior Clinician Scientist Award 2020

Journals & Publications

  1. Mark Y. Chan, Karen W.L. Koh, Sock-Cheng Poh, Stephanie Marchesseau, Devinder Singh, Yiying Han, Faclin Ng, Eleanor Lim, Joseph F. Prabath, Chi-Hang Lee, Hui-Wen Sim, Ruth Chen, Leonardo Carvalho, Sock-Hwee Tan, Joshua P.Y. Loh, Jack W.C. Tan, Karishma Kuwelker, R.M. Amanullah, Chee-Tang Chin, James W.L. Yip, Choy-Yee Lee, Juvena Gan, Chew-Yong Lo, Hee-Hwa Ho, Derek J. Hausenloy, Bee-Choo Tai, A. Mark Richards for the IMMACULATE Investigators. Remote Post-discharge Treatment of Patients with Acute Myocardial Infarction by Allied Health Practitioners vs Standard Care. THE IMMACULATE Randomized Clinical Trial. JAMA Cardiology. 2020 doi:10.1001/jamacardio.2020.6721
  2. Chan MY, Efthymios M, Tan SH, Pickering JW, Troughton R, Pemberton C, Ho HH, Prabath JF, Drum CL, Ling LH, Soo WM, Chai SC, Fong A, Oon YY, Loh JP, Lee CH, Foo RSY, Ackers-Johnson MA, Pilbrow A, Richards AM. Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics. Circulation. 2020 Oct 13;142(15):1408-1421. doi: 10.1161/CIRCULATIONAHA.119.045158. Epub 2020 Sep 4.
  3. Tung BWL, Ng ZY, Kristanto W, Saw KW, Chan SP, Sia W, Chan KH, Chan M, Kong Wi, Lee R, Loh JP, Low AF, Poh KK, Tay E, Tan HC, Yeo TC, Loh PH. Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: Retrospective analysis in a multiethnic Asian population. Open Heart. Jan 2021, 8(1). DOI: 10.1136/openhrt-2020-001437.
  4. Ho JSY, Mui B, Sia CH, Djohan AH, Mok SF, Chan MY, Ambhore AA. A 78-year-old male with inferior ST-segment elevation on electrocardiogram, diabetic ketoacidosis and acute pancreatitis. Cardiovasc Endocrinol Metab. 2020 Dec;9(4):186-188. doi: 10.1097/XCE.0000000000000205. eCollection 2020 Dec.
  5. Park Y, Koh JS, Lee JH, Park JH, Shin ES, Oh JH, Chun W, Lee SY, Bae JW, Kim JS, Kim W, Suh JW, Yang DH, Hong YJ, Chan MY, Kang MG, Park HW, Hwang SJ, Hwang JY, Ahn JH, Choi SW, Jeong YH. Effect of Ticagrelor on Left Ventricular Remodeling in Patients With ST-Segment Elevation Myocardial Infarction (HEALING-AMI). JACC Cardiovasc Interv. 2020 Oct 12;13(19):2220-2234. doi: 10.1016/j.jcin.2020.08.007.
  6. Yeo TJ, Ling LH, Lam CSP, Chong JPC, Liew OW, Teo ZL, Gong L, Richards AM, Chan MY. Cardiac and renal biomarkers in recreational runners following a 21 km treadmill run. Clin Cardiol. 2020 Sep 3;. doi: 10.1002/clc.23459. [Epub ahead of print]
  7. Ho JS, Sia CH, Chan MY, Lin W, Wong RC. Coronavirus-induced myocarditis: A meta-summary of cases. Heart Lung. 2020 Aug 20;49(6):681-685. doi: 10.1016/j.hrtlng.2020.08.013. Epub 2020 Aug 20.
  8. Sim HW, Zheng H, Richards AM, Chen RW, Sahlen A, Yeo KK, Tan JW, Chua T, Tan HC, Yeo TC, Ho HH, Liew BW, Foo LL, Lee CH, Hausenloy DJ, Chan MY. Beta-blockers and renin-angiotensin system inhibitors in acute myocardial infarction managed with inhospital coronary revascularization. Sci Rep. 2020 Sep 16;10(1):15184. doi: 10.1038/s41598-020-72232-y.
  9. Yip C, Seneviratna A, Tan SH, Khaing T, Chan SP, Loh J, Lee CH, Low AF, Drum CL, Poh SC, Gibson CM, Ohman EM, Richards AM, Chan MY. Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. J Thromb Thrombolysis. 2020 Aug;50(2):421-429. doi: 10.1007/s11239-020-02066-y.
  10. Ho JS, Tambyah PA, Ho AF, Chan MY, Sia CH. Effect of coronavirus infection on the human heart: A scoping review. Eur J Prev Cardiol. 2020 Jul;27(11):1136-1148. doi: 10.1177/2047487320925965. Epub 2020 May 18.

Professional Memberships

Journal Editorial Board:

  • Editorial board member, American Heart Journal, 2012-present day
  • Editorial board member, Journal of Thrombosis and Thrombolysis

National Roles:

  • Member of Ministry of Health Acute Myocardial Infarction Outcomes working group 2016-present day
  • Member of National Healthcare Group Domain Specific Review Board (IRB) Domain C (cardiovascular and metabolic) 2015-present day

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