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Prof Lee Tat Leang

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  • Emeritus Consultant, Department of Anaesthesia, National University Hospital


M.B.B.S (Singapore), MMed (Anaesthesia), FANZCA



Special Interests:

Clinical acupuncture and pain management, Neurotransmitters for pain, Novel peptides and pain, Acupuncture and musculoskeletal pain

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Prof Lee is currently working as Professor and Emeritus Consultant at the Department of Anaesthesia, National University Health System. He graduated in 1976 from the University of Singapore and obtained his Master of Medicine (Anaesthesia) and fellowship of the Australian and New Zealand College of Anaesthetists (ANZCA) in 1982 and 1984 respectively. He was awarded the Cecil Gray Prize by ANZCA in 1982. He also holds a certificate in acupuncture and moxibustion from the Chinese Academy of Traditional Chinese Medicine (Beijing, PRC) and he is the clinical director of acupuncture service at the National University Hospital.

Prof Lee has been involved in the process of training and examination in anaesthesia in Singapore since 1985. He was head of department from 1991-2003. He chaired the Specialist Training Committee and the Residency Advisory Committee (RAC) for anaesthesia from 2000-2013 and is still a member of the RAC. He had also served in many national committees - the Chinese Proprietary Medicine Advisory Committee (Chairman), Medicinal Advisory Committee, Specialist Accreditation Board, Traditional Chinese Medicine Practitioners Board, Scientific Review Committee on Claims of Complementary and Alternative Medicine, and MOH Steering Committee for Joint Examinations with ABMS.

Prof Lee had served in many national and international professional organizations - Singapore Society of Anaesthesiologists (President 1992 & 1995); Asian Australasian Regional Section of the World Federation of Societies of Anaesthesiologists (Chairman 1998 – 2002); Asian & Oceanic Society of Regional Anaesthesia & Pain Medicine (President 2005 – 2007); Temporary adviser to WHO (1999 – 2007); past and present member of Editorial Boards include Anesthesia and Analgesia, Pain Practice, Acta Anaesthesiologica Taiwanica, Journal of Acupuncture and Tuina Science, Evidence-Based Complementary and Alternative Medicine, and Open Journal of Anesthesiology.
Prof Lee was awarded the clinician mentor award by the Ministry of Health of Singapore in 2011 for his significant contribution to the specialty, and long service awards by the Ministry of Health, National University of Singapore, and the National University Hospital.

Journals & Publications

  1. Tay AS, Liu EH, Lee TL, Miyazaki S, Nishimura W, Minami T, Chan YH, Low CM, Tachibana S "Cerebrospinal fluid of postherpetic neuralgia patients induced interleukin-6 release in human glial cell-line T98G." Neurochem Int. 2013 Sep 2;63(5):517-521. [Epub ahead of print] PubMed PMID: 24008207.
  2. Liu EH, Li C, Govindasamy M, Neo HJ, Lee TL, Low CM, Tachibana S, "Elevated prepronociceptin, nociceptin/orphanin FQ and nocistatin concentrations in rat chronic constriction nerve injury and diabetic neuropathic pain model." Neurosci Lett 2012; 506: 104-6. Epub 2011 Oct 29.
  3. He HG, Lee TL, Jahja R, Sinnappan R, Vehvilainen-Julkunen K, Polkki T, Neo EKA., "The Use of nonpharmacological methods for children's postoperative pain relief. Singapore Nurses' Perspectives." J Spec Pediatr Nurs 2011; 16:27-38.
  4. He HG, TL Lee, R Jahaja, Emily Neo Kim Ann, Rajammal Sinnappan, K Vehvilainen-Jaulkunen, and MF Chan, "Nurses' use of non-pharmacological methods in children's postoperative pain management: educational intervention study." Journal of Advanced Nursing. 66, no. 11 (2010): 2398-2409.
  5. GM Tan, LK Ti, KH Tan and TL Lee, "A comparison of screen-based simulation and conventional lectures for undergraduate teaching of crisis management." Anaesthesia And Intensive Care 2008 Jul; 36(4): 565-9. (United States).
  6. R Sethuraman, MG Krishnamoorthy, TL Lee, EHC Liu, C Siau, W Nishimura, M Sakai, T Minami and S Tachibana, "Simultaneous Analysis of D- and L-Serine in Cerebrospinal Fluid by Use of HPLC." Clinical Chemistry 2007; 53(8): 1489-1494. (United States). (A sensitive analysis method for D-serine in CSF).
  7. T Joseph, TL Lee, C LI, C Siau, Y Nishiuchi, T Kimura and S Tachibana, "Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model." Peptides 2007 Jul; 28(7): 1433-1440. (United States).
  8. JA Kazi, EHC Liu, TL Lee and S Tachibana, "Localization of nocistatin-binding sites in mice brain and spinal cord using a biotinylated nocistatin probe." Neuroreport 2007 May; 18( 8): 767-770. (United States).
  9. JA Kazi, EHC Liu, TL Lee and S Tachibana, "Nocistatin attenuated the nociceptin induced c-FOS expression in the mouse hippocampus". Neuropeptides 2007; 41(4): 227-31. (United Kingdom).
  10. EHC Liu, TL Lee, Y Nishiuchi, T Kimura and S Tachibana, "Nocistatin and its derivatives antagonize the impairment of short term acquisition induced by nociceptin." Neuroscience Letters 2007 Apr; 416(2): 155-159. (Netherlands).
  11. X Liu, TL Lee and PTH Wong, "Cyclooxygenase-1 inhibition shortens the duration of diazepam-induced loss of righting reflex in mice." Anesthesia And Analgesia 2006 Jan; 102(1): 135-140. (United States).
  12. T Joseph, TL Lee, N Chou, Y Nishiuchi, T Kimura, H Jikuya, K Ou, CC Yau and S Tachibana, "Identification of mature nocistatin and nociceptin in human brain and cerebrospinal fluid by mass spectrometry combined with affinity chromatography and HPLC." Peptides 2006 Jan; 27: 122-30. (United States).
  13. R Sethuraman, TL Lee, JW Chui and S Tachibana, "Changes in amino acids and nitric oxide concentration in cerebrospinal fluid during labor pain." Neurochemical Research 2006; 31(9): 1127-33. (United States).
  14. TL Lee, "Unilateral bronchospasm after interpleural analgesia with bupivacaine."Acta Anaesthesiologica Scandinavica 2006 Apr; 50(4): 518-9. (Denmark).
  15. EHC Liu, HK Wong, CP Chia, HJ Lim, ZY Chen and TL Lee, "Effects of isoflurane and propofol on cortical somatosensory evoked potentials during comparable depth of anaesthesia as guided by bispectral index." British Journal Of Anaesthesia 2005 Feb; 94(2): 193-7. (United Kingdom).

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