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2024/03/11
Doctor Detail

Prof Lee Soo Chin

Photo of Prof Lee Soo Chin

Designations:

  • Senior Consultant, Department of Haematology-Oncology, National University Cancer Institute, Singapore
  • Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore

Qualifications:

MBBS, M.Med, MRCP, FAMS, FRCP

Specialties/Sub-specialties:

Medical Oncology

Clinical Disciplines/Programmes:

Cancer Genetics

Special Interests:

Breast cancer, Cancer genetics, Pharmacogenetics

Find Out More:

Biosketch

Professor Lee obtained her medical degrees from the National University of Singapore and the Royal College of Physicians, United Kingdom, and completed a fellowship in cancer genetics at Johns Hopkins School of Medicine, USA. She was Head of the Department of Haematology-Oncology at the National University Cancer Institute, Singapore (NCIS). She is currently Senior Consultant and Associate Director of Research at NCIS and Professor and Senior Principal Investigator at the Cancer Science Institute, National University of Singapore. She is ex-Chairperson of the Chapter of Medical Oncologists, Academy of Medicine, Singapore, and was a member of the Singapore Ministry of Health Specialist Accreditation Board for Medical Oncology.

She specializes in breast cancer and directs the Cancer Genetics Program at NCIS. Prof Lee is a clinician scientist and has been awarded the National Medical Research Council Singapore (NMRC) Senior Clinician Scientist Award three times. She is also Distinguished Senior Clinician awardee by the Singapore Ministry of Health. Her research interests are in developing novel therapeutics and predictive biomarkers in breast cancer and pharmacogenetics. She sits on drug advisory boards for breast cancer drugs for multiple international pharmaceutical companies and is a Steering Committee member of several international phase III randomized trials evaluating novel therapeutic approaches in breast cancer.

Prof Lee directs the Haematology-Oncology Research Group (HORG), a cancer clinical trials unit that supports ~200 phase I-III therapeutics clinical trials in solid tumors and haematological malignancies at NCIS. She has more than 260 peer-reviewed scientific publications, including publications in high impact journals such as Journal of Clinical Oncology, Annals of Oncology, British Journal of Cancer, Breast Cancer Research and Treatment, New England Journal of Medicine, Nature Genetics and Nature Medicine.

Awards

  • 2021 - National Medical Research Council Awards - Clinician Scientist Award Senior Investigator
  • 2020 - National Day Awards - Long Service Medal
  • 2016 - National Medical Reserach Council Awards - Clinician Scientist Award Senior Investigator

Journals & Publications

  1. Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer. Wong AL, Sundar R, Wang TT, Ng TC, Zhang B, Tan SH, Soh TI, Pang AS, Tan CS, Ow SG, Wang L, Mogro J, Ho J, Jeyasekharan AD, Huang Y, Thng CH, Chan CW, Hartman M, Iau P, Buhari SA, Goh BC, SC Lee. Oncotarget 2016; 7(39): 64089-99.
  2. High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer. Wang T, Srivastava S, Hartman M, Buhari SA, Chan CW, Iau P, Khin LW, Wong A, Tan SH, Goh BC, SC Lee. Oncotarget 2016; 7(34): 55155-68.
  3. Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment. Khoo BL, Grenci G, Jing T, Lim YB, SC Lee, Thiery JP, Han J, Lim CT. Sci Adv 2016; 2(7): e1600274.
  4. Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomized, double-blind, placebo-controlled phase 2 trial. IE Krop, IA Mayer, V Ganju, M Dickler, S Johnston, S Morales, DA Yardley, B Melicha, A Forero-Torres, SC Lee, R de Boer, K Petrakova, S Vallentin, EA Perez, M Piccart, M Ellis, E Winer, S Gendreau, M Derynck, M LAckner, G Levy, J Qiu, J He, P Schmid. Lancet Oncol 2016; 17(6): 811-21.
  5. Phase Ib/2 study of the HSP90 inhibitor AUY922 plus trastuzumab in metastatic HER2-positive breast cancer patients who have progressed on trastuzumab-based regimen. A Kong, D Rea, S Ahmed, JT Beck, RL Lopez, L Biganzoli, AC Armstrong, M Aglietta, E Alba, M Campone, SH Schmitz, C Lefebvre, M Akomov, SC Lee. Oncotarget 2016 Apr 25 (epub ahead of print).
  6. Neratinib plus paclitaxel vs trastuzumab plus paclitaxel in previously untreated metastatic ERBB2-positive breast cancer: The NEfERT-T randomized clinical trial. A Awada, R Colomer, K Ionue, I Bondarenko, RA Badwe, G Demetriou, SC Lee, AO Mehta, SB Kim, T Bachelot, C Goswami, S Deo, R Bose, A Wong, F Xu, B Yao, R Bryce, LA Carey. JAMA Oncol 2016, Apr 14 (epub ahead of print)
  7. Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development. L Wang, DD Phan, J Zhang, PS Ong, WL Thuya, RA Soo, AL Wong, WP Yong, SC Lee, PC Ho, G Sethi, BC Goh. Oncotarget 2016, Mar 2014 (epub ahead of print).
  8. High throughput mutation profiling changes before and 3 weeks after chemotherapy in newly diagnosed breast cancer patients. SH Tan, NS Sapari, H Miao, M Hartman, M Loh, WJ Chng, P Iau, SA Buhari, R Soong, SC Lee. Plos One 2015, Dec 2; 10(12): e0142466.
  9. Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signaling are reversed by metabolic products of the mevalonate pathway. TT 10. Wang, S Seah, XY Loh, CW Chan, M Hartman, BC Goh, SC Lee. Oncotarget 2015, Nov 11 (epub ahead of print).
  10. Genetic factors affecting drug disposition in Asian cancer patients. NL Syn, WP Yong, SC Lee, BC Goh. Expert Opin Drug Metab Toxicol 2015, Dec ; 11(12): 1879-92.

Professional Memberships

  • Member, American Society of Clinical Oncology
  • Fellow and Past Chairperson, Chapter of Medical Oncologists, Academy of Medicine, Singapore
  • Member, Singapore Society of Oncology

2025/10/06
1E Kent Ridge Road, NUHS Tower Block, Singapore 119228
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