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Prof Lee Eng Hin

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  • Emeritus Consultant, Division of Paediatric Orthopaedic Surgery, Department of Orthopaedic Surgery, National University Hospital


MD (W. Ont), FRCS(C), FRCS (Edin), FRCS (Glas), FAMS (Sing)


Orthopaedic Surgery, Sports Medicine

Clinical Disciplines/Programmes:

Paediatric Orthopaedic Surgery


Prof E H Lee specialises in the management of orthopaedic problems in children. His special areas of interest are the care, rehabilitation and surgical treatment of musculoskeletal problems occurring in infants and children, such as hip dysplasia and dislocation, foot deformities, spinal deformities, limb length discrepancies and neuromuscular disorders in children.

Prof Lee completed his medical degree at the University of Western Ontario, London, Canada in 1973 and did his residency training in Orthopaedic Surgery at the University of Toronto Teaching Hospitals.  He obtained his FRCS(C) in Orthopaedic Surgery in 1982 after which he did a fellowship in Paediatric Orthopaedics at the Hospital for Sick Children, Toronto, Canada in 1983. 

Prof Lee is currently Emeritus Professor of Orthopaedic Surgery at NUS and an Emeritus Consultant in the Division of Paediatric Orthopaedics at NUH. He is a Senior Consultant with the Ministry of Health and is a member of several boards and committees in MOH including the Specialist Accreditation Board. He is the Chairman of the Bioethics Advisory Committee and the President of the Disciplinary Commission. 

Prof Lee was previously the Head of the Department of Orthopaedics, NUS, as well as the Dean of the Yong Loo Lin School of Medicine. He has been the recipient of 3 public service awards, including the Public Service Medal, the Public Administration (Silver) Medal, and the President's Social Service Award. Prof Lee is actively involved in undergraduate and postgraduate teaching at NUS. 

Prof Lee is a Deputy Editor of the Journal of Bone and Joint Surgery and Co-Editor of the JBJS Open Access. He is also on the editorial boards of the Journal of Paediatric Orthopaedics A & B and the Journal of Orthopaedic Surgery. He is the author of over 160 scientific research articles, and 32 book chapters. He co-edited a book on Stem Cells which has been adopted as a standard textbook by many centres. He has won numerous awards for excellence in research, including the award for the Most Outstanding Basic Science Research Paper at two of the Annual Meetings of the Paediatric Orthopaedic Society of North America.

His research interests are in tissue engineering and regenerative medicine especially in the use of mesenchymal stem cells and chondrocytes for the treatment of partial growth arrest and articular cartilage defects. He is currently working on the optimisation of chondrogenic differentiation of MSCs by manipulation of biochemical, biophysical, biomechanical, bioelectric factors.

His clinical research interests are in Paediatric Orthopaedics, Trauma and Rehabilitation.


  • 2017: Mentoring Innovation and Leadership in Educational Scholarship (MILES) Award, APMEC
  • 2019: Fellow of International Orthopaedic Research, ICORS
  • 2022: Albert & Mary Lim Award, College of Family Physicians

Journals & Publications

Editorial Boards:

  • Deputy Editor, Journal of Bone and Joint Surgery, USA
  • Co-Editor, Journal of Bone and Joint Open Access, USA
  • Member, Editorial Board, Journal of Paediatric Orthopaedics A, USA
  • Member, Editorial Board, Journal of Paediatric Orthopaedics B, Europe
  • Member, Editorial Board, Journal of Orthopaedic Surgery, Hong Kong
  • Member, Editorial Board, Journal of Orthopaedics, Trauma and Rehabilitation, Hong Kong
  • Member, Editorial Board, Journal of Orthopaedic Science, Japan
  • Member, Editorial Board, Journal of the Malaysian Orthopaedic Association, Malaysia
Latest 10 publications:

  1. Teo AQN, Wong KL, Shen L, Lim JY, Toh WS, Lee EH, Hui JHP.Equivalent 10-Year Outcomes After Implantation of Autologous Bone Marrow-Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation for Chondral Defects of the Knee.
    American Journal of Sports Medicine, (2019, October); 47(12): 2881-2887.
  2. Tee CA, Yang Z, Lu Y, Wu Y, Han J, Lee EH. Improved zonal chondrocyte production protocol integrating size-based inertial spiral microchannel separation and dynamic microcarrier culture for clinical application.
    Biomaterials (2019, November); 220: 119409.
  3. Lu Y, Yang Z, Wu Y, Denslin V, Yu CC, Tee CA, Lim CT, Han J, Lee EH. Label-free separation of mesenchymal stem cell subpopulations with distinct differentiation potencies and paracrine effects.
    Biomaterials (2020, February); 240:119881.
  4. Wu Y, Yang Z, Denslin V, Ren X, Lee CS, Yap FL, Lee EH. Repair of Osteochondral Defects with Pre-differentiated Mesenchymal Stem Cells of Distinct Phenotypic Character Derived From a Nanotopographic Platform.
    American Journal of Sports Medicine (2020, Jun); 48(7):1735-1747.
  5. Wong KL, Zhang S, Wang M, Ren FS, Afizah H, Lai RC, Lim SK, Lee EH, Hui JHP, Toh WS. Intra-Articular Injections of Mesenchymal Stem Cell Exosomes and Hyaluronic Acid Improve Structural and Mechanical Properties of Repaired Cartilage in a Rabbit Model.
    Arthroscopy (2020 August); 36 (8): 2215-2228.e2.
  6. Celik C, Franco-Obregón A, Lee EH, Hui JHP, Yang Z. Directionalities of magnetic fields and topographic scaffolds synergise to enhance MSC chondrogenesis.
    Acta Biomaterialia; (2021 Jan); 119: 169-183.
  7. Kadir ND, Yang Z, Hassan A, Denslin V, Lee EH. Electrospun fibers enhanced the paracrine signaling of mesenchymal stem cells for cartilage regeneration.
    Stem Cell Res & Ther. (2021 Feb); 12(1):100.
  8. Yang YM, Lee EH, Yang Z. Hypoxia conditioned mesenchymal stem cells in tissue regeneration application.
    Tissue Eng Part B Rev. 2022 Jan 10.
  9. Tee CA, Yang Z, Wu YN, Ren XF, Baranski M, Lin DJ, Hassan A, Han J, Lee EH. A Pre-Clinical Animal Study for Zonal Articular Cartilage Regeneration Using Stratified Implantation of Microcarrier Expanded Zonal Chondrocytes.
    CARTILAGE April-June 2022: 1-16, 2022.
  10. Yang Z, Celik C, Parate D, Franco-Obregón A, Lee EH (2022). The application of pulsed electromagnetic field for cartilage regeneration.
    Tissue Eng Part A 28, S-365.

Professional Memberships

Singapore Medical Council

  • Chairman, Committee, CME Co-ordinating Committee, SMC
  • Member, Schools Review Committee, SMC
  • Member, Ethics Committee, SMC
  • Senior Consultant, Ministry of Health
  • Member, Specialist Accreditation Board Accreditation (SAB)
  • Member SAB Accreditation Committee
  • Member, Training and Assessment Standards Committee
  • Member, HMDP Visiting Experts Selection Panel
  • Chairman, Bioethics Advisory Committee
  • Chairman, Human Nuclear Genome Editing Review Group, BAC
  • Chairman, Advisory Committee for Restricted Human Biomedical Research, MOH
  • Member, Regulatory Advisory Panel, MOH
  • Member, Joint MOH-HSA Cell, Tissue, Gene Therapy (CTGT) Services and Products Working
  • President, Disciplinary Commission
  • Member, Health Ethics Capability Committee
  • Member, Board Oversight Committee (BOC) for the Advanced Cell Therapy and Research
  • Member of Grant Review Panel for Large Collaborative Grants
  • Chairman, Selection Panel for the President's Science Award
Professional Bodies
  • Member and Past President, Singapore Orthopaedic Association
  • Fellow, Academy of Medicine, Singapore
  • Member, Singapore Medical Association
Regional & International:
  • Fellow, Royal College of Physicians & Surgeons of Canada
  • Member, Paediatric Orthopaedic Association of North America
  • Member, Canadian Orthopaedic Association
  • Member, British Orthopaedic Research Society
  • Member and Past Council Member, Asia Pacific Orthopaedic Association Charter
  • Member, Past Secretary and President, Paediatric Section, Asia Pacific Orthopaedic Association
  • Member and Past President, ASEAN Orthopaedic Association
  • Member and Past Chairman, ASEAN Orthopaedic Research Society
  • Member, International Paediatric Orthopaedic Think Tank (IPOTT)
  • Member, International Society for Stem Cell Research
  • Member, International Tissue Engineering and Regenerative Medicine Society
  • Honorary Member & Advisor, Tissue Engineering Society of Malaysia
  • Member, Scientific Advisory Committee, Institute for Integrated Cell-Material Sciences, (iCeMS) University of Kyoto, Japan
  • Member, Academic Advisory Board, Arthritis Research Program, University Health Network, University of Toronto, Canada
  • Member, International Bioethics Committee, UNESCO, 2020-2023
  • Vice-Chair (Asia Pacific), International Bioethics Committee, UNESCO, 2022-2023

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