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A/Prof Koh Liang Piu

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  • Senior Consultant, Division of Haematology, Department of Haematology-Oncology, National University Cancer Institute, Singapore
  • Associate Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore


MBBS (S'pore), MRCP



Special Interests:

Leukaemia & Myeloid Disorder (MDS, MPD), Bone Marrow Transplant

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Dr Koh Liang Piu is an Associate Professor at the Department of Medicine, National University of Singapore Yong Loo Lin School of Medicine. He is also a senior consultant at the Department of Haematology-Oncology in the National University Cancer Institute, Singapore (NCIS). 

His research interest is predominantly focused on the use of alternative donor transplant such as haploidentical and umbilical cord blood transplantation. He is the leading investigator on the use ex-vivo T-cell depleted haploidentical transplant for adult patients with haematological malignancies and bone marrow failure syndromes.

A/Prof Koh is the clinical director of the NCIS Adult Haematopoeitic Cell Transplant (HCT) programme at NCIS. Under his leadership, the NCIS Adult HCT programme has expanded and strengthened over the last 15 years, with notable developments such as expansion of the umbilical cord blood and haploidentical transplant programme, bringing the transplant outcome to levels comparable with the European and North American transplant centres. To date, he has performed more than 500 transplant for various haematological diseases.

A/Prof Koh is also the principal investigator of several international, multi-centre phase II/III clinical trials in the treatment of  haematological malignancies, transplant-related infectious complications, studies on the use of umbilical cord transplant, alternative donor transplant, graft-versus-host disease (GVHD) treatment and prophylaxis, and novel approach in transplant conditioning regimens.  He has published more than 70 peer reviewed papers and 3 book chapters on the topic of HCT, and has also presented more than 30 abstracts in international haematology/HCT meetings. He also serves as a reviewer for some of international peer reviewed transplantation or haematology journals such as Blood, Blood Advances, Transplantation, Leukemia and Lymphoma.

Journals & Publications

  1. Boo YL, Koh LP. Hematopoietic Stem Cell Transplantation in T Cell and Natural Killer Cell Lymphomas: Update on Recent Advances. Transplant Cell Ther. 2021 Apr 20; S2666-6367(21)00826-5.
  2. Omidubicel vs standard myeloablative umbilical cord blood transplantation: results of a phase 3 randomized study. Horwitz ME, Stiff PJ, Cutler C, Brunstein C, Hanna R, Maziarz RT, Rezvani AR, Karris NA, McGuirk J, Valcarcel D, Schiller GJ, Lindemans CA, Hwang WYK, Koh LP, Keating A, Khaled Y, Hamerschlak N, Frankfurt O, Peled T, Segalovich I, Blackwell B, Wease S, Freedman LS, Galamidi-Cohen E, Sanz G. Blood. 2021 Oct 21;138(16):1429-1440.
  3. Maertens J, Rahav G, Lee DG, Ponce-de-León A, Ramírez Sánchez IC, Klimko N, Sonet A, Haider S, Vélez J, Raad I, Koh LP, Karthaus M, Zhou J, Ben-Ami R, Motyl M, Han S, Grandhi A, Waskin H, on behalf of the study investigators* Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial. Lancet 2021;397: 499-599.
  4. Horwitz ME, Wease S, Blackwell B, Valcarcel D, Frassoni F, Boelens JJ, Nierkens S, Jagasia M, Wagner JE, Kuball J, Koh LP, Majhail NS, Stiff PJ, Hanna R, Hwang WYK, Kurtzberg J, Cilloni D, Freedman LS, Montesinos P, Sanz G. Phase I/II Study of Stem-Cell Transplantation Using a Single Cord Blood Unit Expanded Ex Vivo With Nicotinamide. J Clin Oncol. 2019 Feb 10;37(5):367-374.
  5. Marr KA, Schlamm HT, Herbrecht R, Rottinghaus ST, Bow EJ, Oliver A. Cornely OA, Heinz WJ, Jagannatha S, Koh LP, Kontoyiannis DP, Lee GD, Nucci M, Pappas PG, Slavin MA, Queiroz-Telles F, Selleslag D, Walsh TJ, Wingard JR, Maertens JA. Combination Antifungal Therapy for Treatment of Invasive Aspergillosis: A Randomized, Controlled Trial. Annals of Internal Medicine. 2015 Jan 20;162(2):81-9.
  6. Koh LP, Chao N. Haploidentical hematopoietic cell transplantation. Bone Marrow Transplant. 2008 ;42 Suppl 1: S60-S63.
  7. Koh LP, Rizzieri DA, Chao NJ. Allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors Biol Blood Marrow Transplant. 2007; 13:1249-67.
  8. Koh LP, Chao NJ. Nonmyeloablative allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors: A review. Blood Cells Mol Dis. 2008; 40:20-4.
  9. Koh LP, Chen CS, Tai BC, Hwang WYK, Tan LK , Ng HY, Linn YC, Koh MBC, Goh YT, Tan B, Lim S, Lee YM, Tan KW, Liu TC, Ng HJ, Loh YSM, Mow BMF , Tan DCL, Tan PHC. Impact of Postgrafting Immunosuppressive Regimens on Nonrelapse Mortality and Survival after Nonmyeloablative Allogeneic Haematopoietic Stem Cell Transplant Using the Fludarabine and Low Dose Total Body Irradiation 200-cGy. Biology of Blood Marrow Transplantation. Biol Blood Marrow Transplant. 2007; 13:790-805.
  10. Rizzieri DA, Koh LP, Long GD, Gasparetto C, Sullivan KM, Horwitz M, Chute J, Smith C, Gong JZ, Lagoo A, Niedzwiecki D, Dowell JM, Waters-Pick B, Liu C, Marshall D, Vredenburgh JJ, Gockerman J, Decastro C, Moore J, Chao NJ. Partially Matched, Nonmyeloablative Allogeneic Transplantation: Clinical Outcomes and Immune Reconstitution. J Clin Oncol. 2007 ;25: 690-7.

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