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A/Prof Yip Wei Luen James

  • Senior Consultant, National University Heart Centre, Singapore
  • Director, National University Heart Centre, Singapore
  • Associate Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore 
  • Joint Associate Professor, Saw Swee Hock School of Public Health, National University of Singapore   
  • Head, Academic Informatics Office, National University Health System
Cardiology (Heart)
Adult Congenital, General Cardiology, Pulmonary Hypertension, Structural Heart Disease & Transcatheter Interventions, Women's Heart Health
Special Interests:
Heart Disease in Pregnancy, Medical Informatics/Analytics, Adult Congenital Heart Disease, Pulmonary Hypertension, Marfan Syndrome


Associate Professor James Yip is presently the Director of National University Heart Centre, Singapore (NUHCS); Senior Consultant in Department of Cardiology, National University Heart Centre, Singapore. He graduated from the Yong Loo Lin School of Medicine, National University of Singapore in 1991 and has been a Fellow of the Academy of Medicine Singapore since 2001. He was trained in adult cardiology at the National University Hospital, Singapore from 1995 to 2001, and was a clinical fellow at Toronto Congenital Cardiac Centre for Adults from 2001 to 2002, where he trained in Adult Congenital Heart disease and pulmonary hypertenstion. He developed the Cardiology Information System which is in use in 4 public hospitals in Singapore.

He has been the Principle Investigator for many international trials in pulmonary hypertension and was in charge of developing the structural heart disease program in NUHS from 2003-2017. He has 4 patents on occlusion devices for closing anatomic cardiac defects and has contributed to numerous peer reviewed journals and 3 book chapters in cardiology and information technology. He has been conferred the Public Administration Medal (Bronze) in 2018 and the Distinguished Senior Clinician Award in 2019. He is also the current Director Designate of the National University Heart Centre, Singapore.


  • ​2019 - Distinguished Senior Clinician Award
  • 2018 - National Medical Excellance Award
  • 2018 - Public Administration Medal (Bronze)

Journals & Publications

​Selected Publications:
1. Zhao X, Zhang JM, Bryant JA, Yap J, Ong CC, Singh D, Lim ST, Yip JW, Chen Y, Zhong L, Tan RS, Tan JL, Chai P, Teo L, Fortier MV, Hong Tan T, Leng S, Ruan W.Elevated Right Atrial Pressure Associated with Alteration of Left Ventricular Contractility and Ventricular-Arterial Coupling in Pulmonary Artery Hypertension.Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:820-823. doi: 10.1109/EMBC.2019.8856814.
2. Chia BL, Yip J, Poh KK. Acute inferior myocardial infarction: the dilemma between anatomic-pathological classification and electrocardiographic diagnosis. Singapore Med J. 2019 Aug;60(8):385-386. doi: 10.11622/smedj.2019087.
3. Noviani M, Saffari SE, Tan JL, Yip JWL, Teng GG, Law WG, Chan GYL, Santosa A, Lim AYN, Hong C, Ng SA, Tay ELW, Ruan W, Yap J, Low AHL. Mortality and hospitalization outcomes of interstitial lung disease and pulmonary hypertension in the Singapore systemic sclerosis cohort. Semin Arthritis Rheum. 2019 Nov 13. pii: S0049-0172(19)30686-9. doi: 10.1016/j.semarthrit.2019.11.005. [Epub ahead of print]
4. Margaret H Y Ma , Sen Hee Tay , Peter P M Cheung , Amelia Santosa , Yiong Huak Chan , James W L Yip , Anselm Mak , Manjari Lahiri Attitudes and Behaviors of Patients With Rheumatic Diseases During the Early Stages of the COVID-19 Outbreak. J Rheumatol. 2021 Jan 1;48(1):35-39. doi: 10.3899/jrheum.200646. Epub 2020 Sep 15.
5. Noviani M, Saffari SE, Tan JL, Yip JWL, Teng GG, Law WG, Chan GYL, Santosa A, Lim AYN, Hong C, Ng SA, Tay ELW, Ruan W, Yap J, Low AHL. Mortality and hospitalization outcomes of interstitial lung disease and pulmonary hypertension in the Singapore systemic sclerosis cohort.Semin Arthritis Rheum. 2020 Jun;50(3):473-479. doi: 10.1016/j.semarthrit.2019.11.005. Epub 2019 Nov 13.
6. White RJ, Jerjes-Sanchez C, Bohns Meyer GM, Pulido T, Sepulveda P, Wang KY, Grünig E, Hiremath S, Yu Z, Gangcheng Z, Yip WLJ, Zhang S, Khan A, Deng CQ, Grover R, Tapson VF; FREEDOM-EV Investigators. Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension: A Double-Blind, Placebo-Controlled Study. Am J Respir Crit Care Med. 2020 Mar 15;201(6):707-717.
7. Kuntjoro I, Tay E, Hon J, Yip J, Kong W, Poh KK, Yeo TC, Tan HC, Caleb MG, Luo N, Wang P. Cost-Effectiveness of Transcatheter Aortic Valve Implantation in Intermediate and Low Risk Severe Aortic Stenosis Patients in Singapore.Ann Acad Med Singap. 2020 Jul;49(7):423-433.
8. Pua CJ, Tham N, Chin CWL, Walsh R, Khor CC, Toepfer CN, Repetti GG, Garfinkel AC, Ewoldt JF, Cloonan P, Chen CS, Lim SQ, Cai J, Loo LY, Kong SC, Chiang CWK, Whiffin N, de Marvao A, Lio PM, Hii AA, Yang CX, Le TT, Bylstra Y, Lim WK, Teo JX, Padilha K, Silva GV, Pan B, Govind R, Buchan RJ, Barton PJR, Tan P, Foo R, Yip JWL, Wong RCC, Chan WX, Pereira AC, Tang HC, Jamuar SS, Ware JS, Seidman JG, Seidman CE, Cook SA. Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients.Circ Genom Precis Med. 2020 Oct;13(5):424-434. Epub 2020 Aug 20.
9. Lim Y, Maaroof SMB, Low TT, Kuntjoro I, Yip JW, Tay E. Help-seeking patterns and funding strategies in patients with pulmonary arterial hypertension on phosphodiesterase-5 inhibitors: an orphan disease with effective but costly treatment. Singapore Med J. 2020 Mar 17. doi: 10.11622/smedj.2020026. Online ahead of print.
10. Chan MY, Koh KWL, Poh SC, Marchesseau S, Singh D, Han Y, Ng F, Lim E, Prabath JF, Lee CH, Sim HW, Chen R, Carvalho L, Tan SH, Loh JPY, Tan JWC, Kuwelker K, Amanullah RM, Chin CT, Yip JWL, Lee CY, Gan J, Lo CY, Ho HH, Hausenloy DJ, Tai BC, Richards AM; Remote Postdischarge Treatment of Patients With Acute Myocardial Infarction by Allied Health Care Practitioners vs Standard Care: The IMMACULATE Randomized Clinical Trial. IMMACULATE Investigators.JAMA Cardiol. 2020 Dec 30:e206721.


For more publications, click here.

Professional Memberships

  • ​2001 - Fellow Academy of Medicine Singapore
  • 1997 - Member Royal College of Physicians United Kingdom


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