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Asst Prof Cyrus Ho

  • Senior Consultant, Department of Psychological Medicine, National University Hospital
  • Assistant Professor, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore
MBBS (S’pore), Dip (Cl Psy) (RCP&S, Ire), MRCPsych (UK), Grad Dip Acupuncture (S’pore), MSc (Research) (S’pore), MSc (App Neurosci) (UK), PhD (S'pore), FAMS (Psy) (S’pore), IFAPA (USA)
General Adult Psychiatry
Special Interests:
Mood disorders, Neuropsychiatry


Dr Cyrus Ho is a general adult psychiatrist, managing psychiatric conditions across the age continuum from adolescence to old age. He is also the clinical lead for the Repetitive Transcranial Magnetic Stimulation (rTMS) service in the Department of Psychological Medicine. He is interested in interfacing between medicine and psychiatry, complex mood disorders, neuropsychiatry and public mental health.

After graduating with a Bachelor of Medicine and Bachelor of Surgery (MBBS) from the National University of Singapore (NUS), Dr Ho obtained a Diploma in Clinical Psychiatry from Ireland. He was conferred memberships to the Royal College of Psychiatrists from the United Kingdom and the College of Psychiatrists of Ireland. In addition to being a Fellow of the Singapore Academy of Medicine, he received the International Fellowship from the American Psychiatric Association. With a keen interest in neuroscience, he earned a Master of Science in Research from NUS based on his work on neuroimaging in depressed and chronic pain patients. He was further awarded Distinction in the Master of Science in Applied Neuroscience from King’s College London. He also obtained a doctorate from NUS for his research work on improving the diagnostic accuracy of depression using multimodal biomarkers. He underwent further neuropsychiatry training at the Montreal Neurological Hospital in Canada and the Royal Melbourne Neuropsychiatry Unit in Australia under the MOH Health Manpower Development Plan (HMDP) award, where he enhanced his expertise in the diagnosis and management of patients with complex neurological and psychiatric needs.

Being an avid researcher, Dr Ho has published more than 320 academic papers in international peer-reviewed journals, including The Lancet, JAMA Pediatrics, Annals of Internal Medicine, Autoimmunity Reviews and Brain, Behavior and Immunity. He is also the Associate Editor for the British Journal of Psychiatry and the Frontiers in Psychiatry. Clarivate Analytics (Web of Science) has recognised him as one of the Most Highly Cited and Influential Researchers in the World for his contributions to cross-field research in 2021 and 2022. 

He teaches at undergraduate and postgraduate levels. He currently serves as the NUS Psychiatry Undergraduate Education Director and is the examiner for the postgraduate clinical examination conducted by the Royal College of Psychiatrists, UK. His recognition in education is exemplified by the several teaching awards that he has received, such as the NUS Annual Digital Education Award, Yong Loo Lin School of Medicine Digital Education Award, Dean's Award for Teaching Excellence and Junior Doctor Teaching Award. He has co-authored four postgraduate guidebooks published by Taylor and Francis and the Mastering Psychiatry Textbook, a popular reference book used by Singapore medical students during their clinical postings.

Always interested in pushing the boundaries of research to effect innovative healthcare, Dr Ho welcomes clinical and research collaboration locally and internationally.


  • NUS Annual Digital Education Award (2023)
  • Yong Loo Lin School of Medicine Digital Education Award (2023)
  • Clarivate Highly Cited Researcher - Cross Field (2022, 2021)
  • NUS Engineering in Medicine pitch-for-fund contest – Award (2021)
  • Dean's Award for Teaching Excellence, NUS (2021,2020, 2018)
  • NUHS Teaching Excellence Award (2021)
  • Japanese Society of Psychiatry and Neurology Fellowship Award (2020)
  • NUS Medicine Fortitude Award (2020)
  • MOH Health Manpower Development Plan (HMDP) Award (2018)                                       

Journals & Publications

  1. Li T, Yuan L, Zhao Y,…, Ho CSH. Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice. J Affect Disord. 2023 Feb 24:S0165-0327(23)00273-2. [IF 6.533]

  2. Ho CSH, Tay GWN, Wee HN, et al. The Utility of Amino Acid Metabolites in the Diagnosis of Major Depressive Disorder and Correlations with Depression Severity. International Journal of Molecular Sciences. 2023 Jan 23; 24(3):2231. [IF 6.208]

  3. Ho CSH, Soh MWT, Tay GWN. The diagnostic utility of miRNA and elucidation of pathological mechanisms in major depressive disorder. Compr Psychiatry. 2022 Dec 23;121:152363.  [IF 7.211]

  4. Lam RW, Wong HK, Kumarsing RA,…, Ho CS. Fluoxetine improves bone microarchitecture and mechanical properties in rodents undergoing chronic mild stress - an animal model of depression. Transl Psychiatry. 2022 Aug 20;12(1):339. [IF 7.989]

  5. Li Z, McIntyre RS, Husain SF,…, Ho CS, Chen N. Identifying neuroimaging biomarkers of major depressive disorder from cortical hemodynamic responses using machine learning approaches. EBioMedicine. 2022 Apr 28;79:104027. [IF 11.205]

  6. Ho CS, Chan YL, Tan TW, et al. Improving the diagnostic accuracy for major depressive disorder using machine learning algorithms integrating clinical and near-infrared spectroscopy data. J Psychiatr Res. 2022 Jan 12;147:194-202. [IF 5.25]

  7. Li H, Xiang Y, Zhu Z,…, Ho CSH. Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat. J Neuroinflammation. 2021 Nov 4;18(1):254. [IF 9.587]

  8. Lee ARYB, Tariq A, Lau G,…, Ho CSH. Vitamin E, Alpha-Tocopherol, and Its Effects on Depression and Anxiety: A Systematic Review and Meta-Analysis. Nutrients. 2022 Feb 3;14(3):656. [IF 6.706]

  9. Husain SF, Ong SK,… Ho CS. Functional near-infrared spectroscopy during a decision-making task in patients with major depressive disorder. Aust N Z J Psychiatry. 2020 Dec 10:4867420976856. [IF 5.598]

  10. Wang C, Pan R,…, Ho C. A Longitudinal Study on the Mental Health of General Population during the COVID-19 Epidemic in China. Brain Behav Immun. 2020 Apr 13. pii: S0889-1591(20)30511-0. [IF 19.227]

Professional Memberships

  • Member, Royal College of Psychiatrists, United Kingdom
  • Fellow (Psychiatry), Academy of Medicine Singapore
  • International Fellow, American Psychiatric Association, United States
  • Member, American Neuropsychiatric Association, United States
  • Member, Academy of Consultation-Liaison Psychiatry, United States
  • Fellow, International Society for Affective Disorders


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