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Centre for Healthy Longevity

Singapore's population is rapidly ageing - people are living longer, while the birth rate remains low.  By 2030, one in four Singaporeans will be 65 years and above, twice the current ratio. In addition, direct costs of elderly healthcare in Singapore are projected to rise tenfold to more than $66 billion. Given the increased prevalence of age-related disease that accompanies the ageing population, this issue may represent the biggest medical challenge of the 21st century. Ageing is the most common and biggest risk factor for most chronic diseases including Alzheimer’s disease, cardiovascular disease, frailty, most forms of cancer and diabetes.

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The Centre for Healthy Longevity will be a multi-disciplinary hub that integrates research and clinical care, providing a holistic strategy to promote healthy living throughout the ageing process, from effective disease prevention in the healthy to novel and compassionate end-of-life care.
A major focus of the Centre is to delay ageing, prolonging disease-free life as well as maintaining high functionality and resilience. The programme will improve the quality of life for people as they age and reduce healthcare costs in Singapore with its ageing population. Maximum impact can be achieved by combining novel strategies to delay the onset of age-related conditions with effective clinical management in the elder population that maximises life quality. The former strategy involves the development of interventions that exploit the pathways modulating human longevity and testing these interventions using newly identified biomarkers of human ageing, as well as prevention of chronic disease onset. Once approaches are validated, the Centre will develop strategies for implementation in the Singapore population.

Our Mission

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To delay ageing and increase human healthspan, prolonging disease-free life and maintaining functionality through leading research in the biology of ageing, development and validation of interventions and novel implementation strategies to extend the healthy lives of Singaporeans.

Our Programmes

Centre Director

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Professor Brian Kennedy

Prof Brian Kennedy is internationally recognised for his research in the basic biology of ageing and as a visionary committed to translating research discoveries into new ways of delaying, detecting, preventing and treating human ageing and associated diseases. He is the Director of the NUHS Centre for Healthy Longevity. He also serves as a Distinguished Professor in Biochemistry and Physiology Yong Loo Lin School of Medicine at National University Singapore. The Centre seeks to demonstrate that ageing interventions can be successfully employed in humans to extend healthspan, the disease-free and highly functional period of life.

From 2010 to 2016 he was the President and CEO of the Buck Institute for Research on Ageing. Currently he remains as a Professor at the Institute, where his lab addresses the biology of ageing. Prof Kennedy has adjunct appointments at the Leonard Davis School of Gerontology at USC and the Department of Biochemistry at the University of Washington, where he was a faculty member from 2001 to 2010. In addition, Prof Kennedy is also actively involved with a number of Biotechnology companies, serving in consulting and Board capacities, and is Scientific Director of Affirmativ Health. In addition, Prof Kennedy serves as a Co-Editor-In-Chief at Ageing Cell. Finally, Prof Kennedy has a track record of interaction in China, where he was a Visiting Professor at the Ageing Research Institute at Guangdong Medical College from 2009 to 2014. His Ph.D. was performed in the laboratory of Leonard Guarente at M.I.T., where he published the first paper linking Sirtuins to ageing. His postdoctoral studies were performed at Massachusetts General Hospital Cancer Centre at Harvard Medical School.

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