MSC aims to be the think-tank and recognised leader in the field of translational mental wellness research. Through the 10-year longitudinal Jurong Ageing Study (JAS), MSC has built a cohort of 1,000 elderly and investigated the efficacy of interventions such as mindful awareness practice, art therapy, music reminiscence, horticulture therapy, choral singing etc. in delaying the onset of dementia and depression. The studies have won MSC a Ministry of National Development Research Fund (MNDRF) Grant and the prestigious National Medical Research Council (NMRC) Grant.

Replicating the successful flagship research, MSC is currently building a new elderly cohort of 1,000 through the Hannah Intergenerational Study, to investigate ageing in place through understanding mental resilience and vulnerability factors of the ageing process in the biological, psychological and social domains. For children and adolescents, MSC is initiating the Singapore Youth Epidemiology and Resilience (YEaR) Study to track the prevalence of psychiatric disorders, resilience and stress among a school-based population of 4,000 youths.