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Clinical Studies

Completed:

  1. A 78-Week NoninterventionalLongitudinal Study to Validate the Alzheimer’s Disease Assessment Scale –Cognitive Subscale (ADAS-Cog), Disability Assessment for Dementia (DAD), and Neuropsychological Test Battery (NTB) in Asian Subjects With Mild to Moderate Alzheimer’s Disease  
  2. Cognitive Outcome After STroke (COAST)  
  3. Translational Research in Dementia: Mechanisms of Diseases, Pathophysiologyand Biomarker Discovery  
  4. The feasibility and validation of an informant-based cognitive screening instrument in the primary healthcare setting  
  5. A multi-national observational study to identify treatment discontinuation rate in de novo Alzheimer’s disease patient who is newly prescribed with donepezil (Aricept®) in Asia   

Ongoing:

  1. Epidemiology of Dementia in Singapore : Ethnicity and Risk Factors   
  2. Retinal Imaging in Dementia   
  3. Improving the Diagnosis of Vascular Cognitive Impairment by Prospective Longitudinal Clinical Studies by a) Improving the Diagnosis of Vascular Cognitive Impairment by Prospective Longitudinal Clinical Studies b) Dementia Neuroimaging using Multi-Modal Magnetic Resonance and Retinal Imaging  
  4. Cognitive Outcome After STroke -Extension (COAST-E)  
  5. An exploratory study to compare the differences in nutritional status between patients with mild and moderate Alzheimer's disease (AD) and cognitively intact healthy people in an Asian population  
  6. Preclinical and clinical investigations of neurodegeneration and age-associated cognitive impairment Project V (Amyloid Brain and Retinal Imaging studies) –ABRI  
  7. PET amyloid-beta imaging in MCI and dementia subjects   
  8. An investigation of visual speed of processing in MCI patients   
  9. Etiology of Cortical Cerebral Microinfarcts and Impact on Brain Function and Long Term Outcomes   
  10. Ocular Markers of Alzheimer’s Disease: OMEGA Study   
  11. Translational Research in Vascular Biomarkers of Dementia: Discovery, Validation and Assessment of Clinical Utility