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Singapore Gastric Cancer Consortium

Home > Research > Research Themes > Major Research Programs > Singapore Gastric Cancer Consortium

 

 

$25mil Translational and Clinical Research Grant over 5 years, by National Research Foundation.

Programme Leaders:

A/Prof Yeoh Khay Guan
Tel    :   6516 3304
Email   :   khay_guan_yeoh@nuhs.edu.sg

A/Prof Patrick Tan
Tel    :   6516 1783
Email   :   gmstanp@duke-nus.edu.sg

Prof Yoshiaki Ito
Tel    :   6516 2242
Email   :   itoy@imcb.a-star.edu.sg

Dr Yong Wei Peng
Email   :   wei_peng_yong@nuhs.edu.sg

 

Principal Investigators:

Prof Bay Boon Huat

Prof Chia Kee Seng

A/Prof Chung Ching Ming, Maxey

Dr Jeffrey Hill

Prof Ho Khek Yu

Asst Prof Huang Zhiwei

Dr Matiullah Khan

Dr Lim Yoon Pin

Dr Ling Khoon Lin

Asst Prof Louis Phee

Adj A/Prof RuanYijun

A/Prof Manuel Salto-Tellez

A/Prof So Bok Yan, Jimmy

A/Prof Richie Soong

Dr Yap Suen Mei, Celestial Therese

Clinical Collaborators:

Dr Chia Chung King

Prof Fock Kwong Ming

Adj A/Prof Goh Boon Cher

Dr Christopher Khor

Dr Lee Soo Chin

Dr Robert Lim

Dr Lim Lee Guan

A/Prof Ooi Choon Jin

Dr Andrea Rajnakova

Dr Ross Soo

Dr Tan Sing Huang

Dr Andrew Wong

A/Prof Wong Wai Keong


Scientific Collaborators:

Prof Jean-Pierre Abastado

Dr Heike Grabsch

A/Prof Ho Bow 

A/Prof Kon Oi Lian

Dr Alessandra Nardin

A/Prof Tan Puay Hoon

A/Prof Teh Ming

A/Prof Markus Wenk 

 

International Collaborators:

  1. International Cancer Biomarker Consortium (ICBC) led by Lee Hartwell, Fred Hutchinson Cancer Centre, Seattle, USA
  2. Cancer Therapeutics Research Group, a multi-centre oncology cooperative group involving five countries: Singapore, Hong Kong, Korea, Taiwan and Australia
  3. The Asia Pacific Research Group for Gastric Cancer, comprising participating centres from 10 Asia-Pacific countries.

 

Contact Details:

A/Prof Yeoh Khay Guan
Lead Principal Investigator

Singapore Gastric Cancer Consortium
Department of Medicine
National University of Singapore
c/o National University Hospital
Main Building Level 3
5 Lower Kent Ridge Road Singapore 119074

 

Email:

enquiries_sgcc@nus.edu.sg

 

Website:

http://medicine.nus.edu.sg/sgcc

Left: A/Prof Yeoh Khay Guan

 

Gastric cancer is the second leading cause of cancer death worldwide, and is particularly common in East Asia. It does not get as much attention as other cancers because of its lower incidence in the West. In Singapore it is the fifth commonest cancer in men, who have a 1:50 lifetime risk of developing gastric cancer. Claiming approximately 330 lives every year in Singapore, diagnosis of gastric cancer usually occurs at a late stage of the disease when treatment is difficult and often unsuccessful. Therefore it is critical to improve early detection and treatment.


 

The Singapore Gastric Cancer Consortium (SGCC) is a national coalition of leading clinicians and scientists working in gastric cancer research. The group focuses on solving important clinical questions to improve the care of gastric cancer patients, facilitated by close interaction between clinicians and scientists, and with synergism that enables biologic discoveries in the laboratory to be validated in the clinical setting. Important research projects include biomarker discovery and validation, the genetic mapping of gastric cancer and clinical trials of new treatment agents.

 


 

Infrastructure for Nation-Wide Research Collaboration in Gastric Cancer


The SGCC led the development of a national gastric cancer database. The harmonization process aims to facilitate and standardize data collection across the 2 cancer centres in Singapore. The effort includes harmonisation of data fields, clinical, staging and pathologic nomenclature and classifications and database semantics. The database captures pathological, treatment, toxicity and outcome data, and is an invaluable and critical resource for researchers to study trends in gastric cancer and cancer care. This will be accessible to researchers in the country.



AIMS

 

The aim of the Singapore Gastric Cancer Consortium is to improve the outcomes for gastric cancer in Singapore. This will be achieved by specific research projects focused along 3 themes (click for more details):

 

 Theme 1: Early Detection by Screening of High Risk Groups

 

 Theme 2: Improving Biologic Understanding of Gastric Carcinogenesis

 

 Theme 3: Improving Treatment by Molecular Profiling of Tumours

 

 

 

Selected Publications


 


Multidetector CT scan showing carcinoma stomach from lesser curvature.
SK Teh, W Zheng, KY Ho, M Teh, KG Yeoh, Z Huang. Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach. British Journal of Surgery (2010),  97(4), 550-557.

 

TL Chang, K Ito, TK Ko, Q Liu, M Salto-Tellez, KG Yeoh, H Fukamachi, Y Ito. Claudin-1 has Tumour Suppressive Activity and is a Direct Target of RUNX3 in Gastric Cancer Epithelial Cells. Gastroenterology (2010), 138(1):255-65.e1-3.

 

CH Ooi, T Ivanova, J Wu, MH Lee, I B.H Tan, J Tao, L Ward, JH Koo, V Gopalakrishnan, YS Zhu, LL Cheng, J Lee, SY Rha, HC Chung, K Ganesan, J So, KC Soo, D Lim, WH Chan, WK Wong, D Bowtell, KG Yeoh, H Grabsch, A Boussioutas, and P Tan. Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer. PLoS Genet (2009), 5(10):e1000676.

 

M Loh, KX Koh, BH Yeo, CM Song, KS Chia, F Zhu, KG Yeoh, J Hill, B Iacopetta, R Soong. Meta-Analysis of Genetic Polymorphisms and Gastric Cancer Risk: Variability in Associations According to Race. European Journal of Cancer (2009), 45, 2562 – 2568.

 

K Ito, K-i Inoue, S-C Bae and Y Ito. Runx3 expression in gastrointestinal tract epithelium: resolving the controversy. Oncogene (2009) 28, 1379-1384.

 

Z Huang, SK Teh, W Zheng, J Mo, K Lin, X Shao, KY Ho, M Teh, KG Yeoh .Integrated Raman spectroscopy and trimodal wide-field imaging techniques for realtime in vivo tissue Raman measurements at endoscopy. Optics Letters(2009), Vol.34, No.6, 758-760.

 

SJ Phee, KY Ho, A Shabbir, SC Low, VA Huynh, AP Kencana, K Yang, D Lomanto, B.Y So, SC Chung. Endoscopic Submucosal Dissection of Gastric Lesions Using Through-The-Scope Intuitive Controlled Robotics-Enhanced Manipulator System. Gastrointestinal Endoscopy (2009), Vol. 69, Issue 5, pp AB163.

 

K Ito, A C.B Lim, M Salto-Tellez, L Motoda, M Osato, L S.H Chuang, C W.L Lee, D C.C Voon, J K.W Koo, HJ Wang, H Fukamachi, and Y Ito. RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell (2008). 14, 226–237.

 

WK Leung, MS Wu, Y Kakugawa, J J Kim, KG Yeoh, KL Goh, KC Wu, DC Wu, J Sollano, U Kachintom, T Gotoda, JT Lin, WC You, E K.W Ng, J J.Y Sung, Asia Pacific Working Group on Gastric Cancer. Screening for Gastric Cancer in Asia: Current Evidence and Practice. The Lancet Oncology Mar (2008), 9, 279 – 287.

 

Q Liu, M Teh, K Ito, N Shah, Y Ito, KG Yeoh. CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. Modern Pathology (2007); 20; 1286-1297.