Jul 2010
NUS-Mindef Joint Applied R&D Cooperation Programme (Feb 2010 Grant Call)
| S/N |
Project Title |
PI |
Department |
| 1 |
Molecular epidemiology of seasonal and pandemic influenza in a semi-closed setting. |
Paul Ananth Tambyah |
Medicine (SoM) | |
Jun 2010
NKF Research Grant (Jan 2010 Grant Call)
| S/N |
Project Title |
PI |
Department |
| 1 |
Minimising renal dysfunction in paediatric liver transplant recipients with closer monitoring of renal function and optimising immunosuppression using the Cylex®lmmuKnowTM assay. |
Marion M. Aw |
Paediatrics (SoM) |
| 2 |
The Role of Immune Monitoring in Predicting Acute and Chronic Complications Among Renal Transplant Recipients. |
Anantharaman Vathsala |
Medicine (NUH) |
| 3 |
Prospective one year follow up of acute kidney injury in septic patients admitted to medical ICU. |
Mukhopadhyay Amartya |
Medicine (NUH) |
| 4 |
Portable, non-invasive dry weight assessment and vascular access monitoring using modern bioimpedance analysis for optimal management of hemodialysis patients. |
Victor Lee Tswen Wen |
Surgery (NUH) |
SICS Request for Proposals (2nd Grant Call for Proposals)
| S/N |
Project Title |
PI |
Department |
| 1 |
Nutrition studies and dietary intervention in individuals with type 2 diabetes mellitus of Chinese, Malay and Indian ethnicity. |
Khoo Yin Hao, Eric |
Medicine (SoM) | |
May 2010
NMRC Nov 2009 Grant Call
| Type |
Project Title |
PI |
Department |
| EDG |
Evaluation and screening of scorpion sodium channel toxins for potential antitumor activity |
Bay Boon Huat |
Anatomy (SoM) |
| EDG |
Evaluation of the anti-cancer function of autophagy in a zebrafish liver cancer model |
Shen Han-Ming |
EPH (SoM) |
| EDG |
Identifying Potential Biomarkers Functionally Linked to t(4;14) Multiple Myeloma Using Plasma Membrane Proteomics |
Chng Wee Joo |
Medicine (SoM) |
| EDG |
Development of a novel mouse model of Enterovirus 71 infection |
Alonso, Sylvie |
Microbiology (SoM) |
| EDG |
Derivation of induced pluripotent stem cells from the reprogramming of human adipose-derived mesenchymal stem cells |
Lim Susan |
Orthopaedic Surgery (SoM) |
| EDG |
Gene expression profile of solute carrier (SLC) transporters and their roles in the uptake of antiretroviral drugs across human T4 lymphocytes |
Edmund Jon Deoon Lee |
Pharmacology (SoM) |
| EDG |
Epigenetic regulation of muscle differentiation |
Reshma Taneja |
Physiology (SoM) |
| EDG |
Investigation of the therapeutic effects of soluble IL-18 decoy receptor in keloid scars |
Phan Taon Thang |
Surgery (SoM) |
| EDG |
Autologous cord blood cells for brain injury in term newborns |
Lee Jiun |
Neonatology (NUH) |
| NIG |
Does a mutation at the KCNQ1 locus that confers susceptibility to type 2 diabetes mellitus also cause QT abnormalities in patients with type 2 diabetes mellitus? |
KHOO CHIN MENG |
Medicine (SoM) |
| NIG |
The Role of Immune Monitoring in Predicting Acute and Chronic Complications Among Renal Transplant Recipients |
Yue-Harn Ng |
Medicine (NUH) |
| NIG |
Association of placental syncytiotrophoblast membrane micro-particles with maternal immune response in recurrent pregnancy loss. |
Sheila Vasoo |
Medicine (NUH) |
| NIG |
A phase II trial of preoperative concurrent chemotheraphy and intensity modulated radiotherapy (IMRT) in locally advanced rectal cancer |
Jeremy Tey |
Radiation Oncology (NUH) |
| IRG |
Identification of Prognostic Biomarkers for Hepatocellular Carcinoma |
Chung Ching Ming, Maxey |
Biochemistry (SoM) |
| IRG |
Suppression of AMPK as a novel cancer chemotherpeutic strategy via inhibition of autophagy |
Shen Han-Ming |
EPH (SoM) |
| IRG |
Statistical Methods for Secondary Analysis of Nested Case-Control Data |
Agus Salim |
EPH (SoM) |
| IRG |
Immunology and Immunopathology of Influnza A Infection |
David Michael Kemeny |
Microbiology (SoM) |
| IRG |
Novel Approaches to Promote Vascular Regeneration and Tissue Healing in Orthopaedic Surgery Via Biomaterial Functionalization |
Dr Wilson Wang Ee Jen |
Orthopaedic Surgery (SoM) |
| IRG |
The Purification and Use of FGF-2-Binding Heparan Sulfate to Increase the Healing of Critical-Sized Bone Defects |
James Hui Hoi Po |
Orthopaedic Surgery (SoM) |
| IRG |
Identification of Cell-Associated and Soluble Mediators that Modulate the Inflammatory Microenvironment in Classical Hodgkin Lymphoma |
Lim Yaw-Chyn |
Pathology (SoM) |
| IRG |
Involvement of the Forebrain Theta Network of Structures in Acute and Chronic Pain |
Sanjay Khanna |
Physiology (SoM) |
| IRG |
The molecular epidemiology of influenza in a tropical country |
Tang Julian Wei-Tze |
Laboratory Medicine (NUH) |
A*STAR-NKTH Sep 2009 Grant Call
| S/N |
Project Title |
PI |
Department |
| 1 |
GAGPharma: Development of Bioactive Anti-Cancer Glycosaminoglycan Oliogosaccharides for Breast Carcinoma Treatment |
George Yip |
Anatomy (SoM1) |
| Peter Fugedi |
Carbohydrate Chemistry (HAS2) |
| 2 |
Reverse Signal Transduction of Tumor Necrosis Factor Superfamily Members |
Herbert Schwarz |
Physiology (SoM) |
| Erno Duda |
Medical Biology (ASGMC3) |
Notes:
1 Yong Loo Lin School of Medicine, National University Singapore
2 Hungarian Academy of Sciences
3 Albert Szent-Gyorgyi Medical Center, University of Szeged
VISA Feb 2010 Grant Call
| S/N |
Project Title |
PI |
Department |
| 1 |
A pilot study of the effectiveness of a low vision self-management program for older Chinese people with low vision in Singapore |
Dr Vicki Drudy |
Alice Lee Centre for Nursing Studies (SoM) |
| 2 |
Molecular mechanisms underlying aging-related decline of muscle regeneration |
A/Prof Reshma Taneja |
Physiology (SoM) |
| 3 |
The association between diet and health status in Asian elderly: a pilot study. |
Dr Feng Lei |
Psychological Medicine (SoM) |
| 4 |
Molecular basis of age-associated deficiency in cystathione--lyase in human lens epithelial cells: relevance in senile cataractogenesis. |
A/Prof Deng Lih Wen |
Biochemistry (SoM) | |
April 2010
BMRC Bedside and Bench Grant
| NUHS PI |
Department |
Title of Research |
| A/P Tai E Shyong |
Medicine |
Using functional genetic variants to understand the mechanism of chronic metabolic disease and to prioritize therapeutic targets for their treatment |
| Prof Wong Hee Kit |
Orthopaedic Surgery |
Genetic Prognostication of Curve Progression in Adolescent Idiopathic Scoliosis in Asian School Children |
BMRC May 2009 Grant Call
| S/N |
Project Title |
PI |
Department |
| 1 |
Neurodegeneration in apolipoprotein E4 carriers: the regulation of mTOR1 by labile zinc as a new mechanism of action |
Barry Halliwell |
Biochemistry |
| 2 |
A study to investigate the activation of a new Akt/NHE-1 "feedback loop" in the redox regulation of survival in normal and tumour cells |
Marie Veronique Clement |
Biochemistry |
| 3 |
Molecular characterization of cellular receptor(s) and viral attachment domain of Chikungunya virus: possible implications for anti-viral therapy and vaccine development |
Chu Jang Hann, Justin |
Microbiology |
| 4 |
Intrauterine gene therapy of haemophilia in a non-human primate model |
Jerry Chan |
O&G |
| 5 |
Functionalization of Bioresorbable Poly-Apsilon-Caprolactone-20% Tricalcium Phosphate Cage Devices to Enhance Delivery of Biological Factors in Interbody Spine Fusion |
Wong Hee Kit
|
Orthopaedic Surgery |
| 6 |
Development of andrographolide and its derivatives for the treatment of allergic asthma and asthma exacerbation |
Fred Wong Wai Shiu |
Pharmacology |
| 7 |
Development and spatial expressions of NR3B subunit in rat brain and functional properties of Nr3B-containing N-methyl-D-aspartate receptors |
Low Chian-Ming |
Pharmacology |
| 8 |
Investigating the isoform-specific effects of apolipoprotein E on N-methyl-D-aspartate receptor (NMDAR) signalling during age-related memory decline |
Wong Boon Seng |
Physiology |
| 9 |
Virus-induced host cubic membranes: a novel biomarker and target for understanding and combating viral infections |
Deng Yuru |
Physiology |
| 10 |
Ablation of alternatively spliced exon 33 or Cav1.2 channel by genetic targeting in mouse: implications in functions of cardiovascular and nervous system |
Soong Tuck Wah |
Physiology |
MOH HSR (August 2009 Grant Call)
| S/N |
Project Title |
PI |
Department |
| 1 |
The health, social and financial effects of care-giving among primary and secondary domestic caregivers of elderly stroke patients in the first post stroke year: a prospective cohort study |
Gerald CH Koh |
EPH (SoM) |
| 2 |
Developing and testing the new, 5-level EQ-5D questionnaire for health services research in Singapore |
Luo Nan |
EPH (SoM) |
| 3 |
Evidence based psotoperative monitoring stratification protocol - Use of the Surgical Risk Score (SRS) to enhance monitoring capabilities |
Raymond Goy Wee Lip |
Anaesthesia |
| 4 |
Colonoscopy quality and safety in public hospitals in Singapore |
Yeoh Khay Guan |
Medicine |
NMRC Clinician Scientist Award (October 2009 Grant Call)
| S/N |
Project Title |
PI |
Department |
| 1 |
Singapore Heart Failure Outcomes and Phenotypes. |
Carolyn Lam Su Ping |
Medicine (SoM) |
| 2 |
Individualizing doses and predicting drug-drug interactions for anti-cancer and anti-HIV medications metabolized by UDP-glucuronosyltrasferases. |
Lawrence Lee Soon-U |
Medicine (SoM) |
| 3 |
Translational pipeline: Developing novel therapeutics for cancer treatment, including the role of histone deacetylase inhibitors. |
Adj A/Prof Goh Boon Cher |
Haema-Onco (NUH) |
NRF-POC (October 2009 Grant Call)
| S/N |
Project Title |
PI |
Department |
| 1 |
Partial breast reconstruction using a nanofibrous scaffold following breast-conserving surgery. |
CHAN Ching Wan |
Surgery (SoM) |
| 2 |
CDH17 Marker as a Novel Target for Liver and Stomach Cancer Therapies. |
John M Luk |
Pharmacology (SoM) |
| 3 |
Development of a Novel Bioabsorbable Drug Eluting Ventilation Tube for Chronic Middle Ear Effusion. |
Lynne Lim |
Otolaryngology (SoM) | |
March 2010
2nd NUHS Cross – Department Grant
| S/N |
Project Name |
Name of PIs |
Department |
| 1 |
Comparison of the characteristics of hepatitis C virus proteins of genotypes 1b and 2a |
A/P Tan Yee Joo |
Microbiology |
|
A/P Lim Seng Gee |
Gastroenterology & Hepatology |
| 2 |
Development of suture materials with improved tendon repair qualities |
Dr Wilson Wang En Jen |
Orthopaedic Surgery |
|
Dr Gijsbert Grotenbreg |
Microbiology |
| 3 |
Validation of quality of life instruments for assessing patients with end-stage renal disease (ESRD) |
Dr Luo Nan |
Epidemiology & Public Health |
|
Dr Titus Lan |
Medicine |
| 4 |
Investigating possible links between chromosome condensation and cancer |
Dr Yeong Foong May |
Biochemistry |
|
Dr Sng Jen-Hwei |
Surgery |
| 5 |
Differential expression of drug transporters in hematopoietic progenitor and leukemic cells |
Prof Edmund Jon Deoon Lee |
Pharmacology |
|
A/P Yeoh Eng Juh Allen |
Paediatrics |
| 6 |
Examine the effectiveness of a music intervention on pain and anxiety for patients receiving chemotherapy: a randomized controlled trial |
Dr Moon Fai Chan |
Alice Lee Centre for Nursing Studies |
|
Emily Neo Kim Ang |
National University Cancer Institute, Singapore |
| 7 |
Impact of respiratory viral infections in the first 2 years of life on persistent allergic and non-allergic rhinitis in childhood |
A/P Goh Yam Thiam, Daniel |
Paediatrics |
| Dr Julian Tang |
Microbiology |
| 8 |
Depression and inflammatory bowel disease in animal models: Exploration of immunological signalling mechanism and reversibility with antidepressant treatment |
Dr Roger CM Ho |
Psychological Medicine |
| Dr Alan YW Lee |
Physiology |
| 9 |
Regulatory factors of CD151 expression in non-small cell lung cancer |
Dr Tam, John Kit Chung |
Surgery - CTVS |
| Dr Tran, Thai |
Physiology |
| 10 |
Oseltamivir resistance in pandemic influenza A (H1N1/2009) viruses detected at National University Hospital - a retrospective and prospective study |
Dr Julian Tang |
Laboratory Medicine |
| A/P Paul A Tambyah |
Medicine |
| 11 |
Comparison of viral etiologies in provoked (benign afebrile) seizures and in febrile seizures in healthy children |
A/P Stacey Tay |
Paediatrics |
| A/P Evelyn SC Koay |
Laboratory Medicine / Pathology |
1st NUS Medicine - Engineering Grant
| S/N |
Project Name |
PIs |
Department |
| 1 |
Fabrication of growth factor eluting nano-porous tubes from polymeric-bioceramic composites for orthopaedic tissue engineering applications |
Prof Wong Hee-Kit |
Orthopaedic Surgery (SoM) |
| A/P Zhang Yong |
Bioengineering (FoE) |
| 2 |
Barrier membrane for Cardiovascular and Skin Tissue Engineering |
Dr Jane Lim |
Reconstructive & Aesthetic Surgery (SoM) |
| Prof Teoh Swee Hin |
Mechanical Engineering (FoE) |
| 3 |
Real-time continuous perfusion monitoring of liver allograft in liver transplantation with a wireless vascular flow sensor |
Dr Victor Tswen Wen |
Surgery (SoM) |
| Dr Lian Yong |
Electrical and Computer Engineering (FoE) |
| 4 |
New Methodologies for Functionalizing Catheters to Inhibit Bacterial Adhesion and Colonization |
Dr Edmund Chiong |
Surgery (Urology) (SoM) |
| Prof Neoh Koon Gee |
Chemical and Biomolecular Engineering (FoE) |
| * |
SoM |
: NUS Yong Loo Lin School of Medicine |
|
FoE |
: NUS Faculty of Engineering |
February 2010
Proof-of-Concept Grants
| Name of Staff |
Department |
Project Name |
| Dr Chan Ching Wan |
General Surgery |
Partial breast reconstruction using a nanofibrous scaffold following breast-conserving surgery. |
| A/Prof John Luk |
Pharmacology |
CDH17 Marker as a Novel Target for Liver and Stomach Cancer Therapies. |
| Asst Prof Kevin Tan |
Microbiology |
Fluorescent Tagged Antimalarials as Commercial Molecular Probes to Diagnose Drug Resistance and to Study Diseases |
| A/Prof Lynne Lim |
ENT |
Development of a Novel Bioabsorbable Drug-Eluting Ventilation Tube for Chronic Middle Ear Infection. |
For more information, please refer to NRF Press Release, 13 Feb 2010.
Academic Research Fund – Tier 1 Grant
Faculty Research Committee
| S/N |
Project Name |
PI |
Department |
| 1 |
Further Exploration of Adrenomedullin as a Novel Therapeutic Peptide for Lupus Nephritis using MRL/lpr Mouse Model |
Anselm Mak |
Medicine |
| 2 |
Investigating the Biologic Role and Clinical Relevance of RUNX Genes in NK/T -Cell Lymphoma |
Ng Siok Bian |
Pathology |
| 3 |
Exploring the Molecular Functions of the Pluripotency and Reprogramming Factor Lin 28 |
Wu Qiang |
Biochemistry |
| 4 |
Targeting Constitutive and Interleukin-6-inducible STAT-3 Signaling Cascade in Head and Neck Cancer by Novel Histone Acetyltransferase Inhibitor |
Gautam Sethi |
Pharmacology |
| 5 |
c-Abl is a Positive Regulator of Telomerase and Governs Telomerase Translocation in Different Cellular Compartments |
Wang Xueying |
Biochemistry |
| 6 |
Exploring the Impacts of Anxiety, Depression and Family Function of Couple after Intrauterine Death, Stillbirth, or Neonatal Death |
Chan Moon Fai |
Nursing |
| 7 |
Preparation and Application of a New Type of Calixarene- and Crown Ether-capped Cyclodextrin-bonded Chiral Stationary Phases for Fast and High-Resolution Chiral Druf Separations |
Gong Yinhan |
O&G |
| 8 |
Evaluation of Stemness, Growth Behavious and Safety of Human umbilical Cord Matrix Stem Cells |
Fong Chui Yee |
O&G |
| 9 |
Does Pyruvate Metabolism Determine Tumour Malignancy? |
Sit Kim Ping |
Biochemistry |
| 10 |
Study of the Physiological Ramifications of Chemotherapeutic Agents using Fission Yeast |
Chen Ee Sin |
Biochemistry |
| 11 |
Elucidating Mechanism of Glucose Remission Post-Bariatic Surgery using MicroRNA Analysis |
Khoo Chin Meng |
Medicine |
|
