NUHS has a very important track record of clinical research, hosting more than 100 clinical projects carried out within the National University Hospital and National University Singapore. This has led to discoveries that are reshaping the way we practice medicine, in Singapore and internationally.
In 2010, our institution hosted 28 new PI-initiated clinical trials and 25 new sponsored clinical trials, with an estimate of 4744 patients actively participating in ongoing trials. The Investigational Medicine Unit (IMU) remains as our flagship centre within NUHS, established as a key centre to integrate ongoing research programmes to promote experimental therapeutics and investigational medicine discoveries into interventions that can advance patient care. Specially configured for the conduct of Good Clinical Practice compliant studies, the IMU concentrates on early research in humans, including Proof of Concept, Phase 1 and Phase 2a trials for novel drugs and diagnostics. Apart from the IMU, clinical trials are carried out within the clinic areas of the hospital.
NUHS has secured considerable amount of research funding over the last four years, not to mention those of which are supporting current ongoing large research programs including Research Centre of Excellence grant to the Cancer Science Institute valued at $172 million awarded in FY08 over 7 years, three Translational Clinical research grants for research in Gastric Cancer, Metabolic Medicine & Eye diseases awarded at $25 million per grant in FY 2007 and 2008 over 5 years.
For FY 2010, NUHS received a total of $60.8 million of individual grants from major funding agencies including NMRC, BMRC, A Star, NRF and MOE. A total of 978 publications in peer reviewed journals were published as well. Out of this 978 publications, 307 were the top tier publications, including several published in the Science, Nature, Lancet and New England Journal of Medicine.
Committed to excellence in Clinical Trials and Clinical Research in general. NUHS is re-shaping the campus to expand its building and infrastructural support for the conduct of translational and clinical research. A few key developments include the Centre for Translational Medicine (MD6), MD1, NUH Medical Centre and the remodeling of NUH Main Building, all of which will cater and support the development of Translational Clinical research from first quarter of 2012 and beyond.
The goal of the NUHS Research Office, in the area of Clinical Research, is to create and monitor the appropriate milieu to pursue excellence in clinical research. By doing so, the NUHS Research Office will promote a dynamic research culture and passion towards research amongst NUHS clinicians.
One of the major objectives in clinical research today is to understand the Asian phenotype and to accelerate biomarker and drug developments. This will allow us to develop personalized medicine and complement similar efforts in the West so as to greatly benefit Asia and maximize the potential of an academic hospital as well as develop synergies with A*STAR, other universities and research institutions in Singapore, and industry.
In an effort to help us achieve our goals, The Investigational Medicine Unit (IMU) remains as our flagship centre within NUHS, established as a key centre to integrate ongoing research programmes to promote experimental therapeutics and investigational medicine discoveries into interventions that can advance patient care.
Specially configured for the conduct of Good Clinical Practice compliant studies, the IMU has established
outstanding capabilities to design, carry out and learn deeply from proof-of-concept and early phase studies in man, which seek to validate new diagnostics and treatments.
IMU serves as one of the main NUHS core facility that provides resources to facilitate clinical research.
Services provided include:
Clinical research support
Training in Clinical Trial Management,
Archival of Trial Documents
Storage of Trial Drugs and Biological Samples.
for more information
Clinician researchers can tap upon IMU’s facilities to gain access to scientific expertise provided by clinician-investigators, clinical pharmacologists, biostatisticians and other support staff.
For further enquiry, you may contact IMU.
Under Construction . . .
1. Ethics Review at NUH
All research projects involving human subjects and conducted by/or under the direction of any employee of NUH; and all research conducted using property or facility of NUH will require ethics review and approval. Such research proposals are reviewed by the NHG Domain Specific Review Board (DSRB) since 1st April 2004.
Making DSRB Application
Ethics reviews at NUH are carried out by the NHG Domain Specific Review Board (DSRB). With effect from 24 Jun 2011, DSRB has implemented a NHG ROAM system for the submission of new study applications. Applicants are encouraged to create their personal account and submit their studies for ethics review through this system.
Online DSRB Application
NHG Clinical Trial Insurance for Principal Investigator-initiated trials
Insurance coverage for PI-initiated trials, reviewed by Domain Specific Review Board (DSRB) and conducted in National University Hospital, is provided by the NHG blanket clinical trial insurance.
For enquiries, please email Timothy Chia, firstname.lastname@example.org.
2. Clinical Trial Certificate
All clinical trials on medicinal products conducted in Singapore require Clinical Trial Certificates (CTC) from the Health Products Regulation Group (HPRG), Health Sciences Authority. CTC is not required for clinical trials conducted on medical devices.
Making CTC Application (For trials of medicinal products only)
Applicants should write to NUHS Research Office (email@example.com) with the following information for registration of a PRISM@HSA account:
- Name of PI/Study Coordinator
- IC number of PI/Study Coordinator
Note: Access to the PRISM@HSA is via the SingPass login. Therefore, PI/Study Coordinator should ensure that they have a SingPass login in order to complete this process.
Online CTC Application
Upon creation of PRISM account, make online CTC application here.
Applicants are to complete all sections of CTC application except Section 7 (to be completed by NUHS Research Office).
3. Review of Clinical Trials/Clinical Research Agreements (for sponsored trials)
NUHS Research Office reviews the legal aspects of clinical trial and other related clinical research agreements.
Please note that review of Clinical Trial Agreement (CTA) must be carried out to ensure that the terms and conditions are in line with NHG guidelines.
Request for Clinical Trials/Clinical Research Agreements Review
For submission of CTA review, please submit the following documents to us via email firstname.lastname@example.org
1. Draft Clinical Trial/ Clinical Research Agreement
2. Request for Legal review form (applicable for all Agreements)
4. Internal Order number (for sponsored trials)
Principal Investigator or Trial Study Coordinator are required to complete the Internal Order application form after DSRB has been approved, with a copy of the Clinical Trial Certificate and the signed copy of the Clinical Trial Agreement. Please complete the section under ‘Application for IO Funded by External Party’ and attach a scan copy of the above mentioned documents. The completed document has to be submitted to NUHS Research Office via email (email@example.com) for processing.
The Internal Order application form can be found here
5. Clinical Trials Registration
The International Committee of Medical Journal Editors (ICMJE) has established a requirement that all clinical trials be entered in a public registry before the onset of patient enrollment, as a condition of consideration for publication. New Trials (started after 1 July 2005) must be registered before enrollment of the first patient.
Please contact your respective departmental representative or firstname.lastname@example.org for the login ID and password to enable Clinical Trial
Clinical trials can be registered on ClinicalTrials.gov.
A guide for clinical trial registration is found here.
Useful Links and Documents
NHG Research Online Home
NHG Research Online downloads
Quality, Environment, Health & Safety (QEHS) Intranet (only NUH users)
Support for Clinical Research
It is the goal of NUHS to provide and maintain continued advancement and growth in clinical research through the training and development of clinicians. As an academic medical centre, NUHS fosters high-quality, meaningful research among clinicians, regardless of the specific portion of their time devoted to research. NUHS provides the necessary infrastructure, facilitates the application of grant funding, generated internal funds to support clinical research, and monitors the performance of our clinicians to encourage research growth.
Awards, Grants & Scholarships
There are numerous scholarships offered by MOH, NUS Yong Loo Lin School of Medicine and general funding agencies such as NRF, NMRC and A*STAR. This large number of support initiatives encompasses all levels of seniority, all types of training and professional development, and all forms of clinically related research.
One of the tasks of the NUHS Research Office is to guide the interested clinician through all the available opportunities, to tailor the best support to the individual's interest. Information on applications for grants, scholarships and other programmes can be accessed from the links specified on the chart as below;
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Training & Education Provided by NHG
NHG provides a number of courses to help investigators as well as clinical research support staff gain the fundamentals of carrying out clinical research.
Courses that are provided include:
- Proper conduct of research courses
- Health Services Research courses
- Research Methodology Courses
- Research Ethics Courses
- Special Programs for Principal Investigators
For more information, please click on the link below: